Eflornithine (70052-12-9)

Efllornithine Chemical Structure

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What is Eflornithine?

Eflornithine is a fluoroamino acid consisting of ornithine with a difluoromethyl group replaced at position 2. It can either be administered intravenously (by way of injection into a vein) or topically. It is commonly sold as a cream under the brand name Vaniqa. It is an antiprotozoal and decarboxylase inhibitor.

It was discovered in the 1970s and began to be utilized in medicine in the year 1990. It is on the World Health Organization’s List of Essential Medicines.

The product is currently under development. Samples are available from R&D.
PRODUCT SPECIFICATIONS
Name of Product Eflornithine
IUPAC Name 2,5-diamino-2-(difluoromethyl)pentanoic acid
Synonyms Ornidyl; Eflornitina; Éflornithine; 2-(Difluoromethyl)ornithine; dfmo; Vaniqa; Eflornithinum
CAS No 70052-12-9
Molecular Formula C6H12F2N2O2
Molecular Weight 182.17 g/mol
Pubchem CID 3009
Pubchem SID 473127232

Uses

  • Eflornithine in combination with Nifurtimox is used for the treatment of sleeping sickness or trypanosomiasis.
  • Eflornithine topical cream is indicated for the treatment of face hirsutism in women. It is the only topical prescription medication that inhibits facial hair growth.
  • It also has anticancer potential and is a supported chemopreventive therapy for colon cancer when combined with other drugs.

Side effects

The side effects associated with the topical use of Eflornithine are as follows:

  • Acne
  • Dry Skin, Itching
  • Burning Discomfort
  • Stinging Sensation
  • Erythema, Rash
  • Hair follicle inflammation

Some serious side effects associated with the systemic use of Eflornithine include:

FAQs

Q. How does topical application of Eflornithine treat facial hirsutism?

In the skin, Eflornithine produces an irreversible inhibition of the chemical which plays a role in the production of facial hair.

Q. Is Eflornithine cream over the counter?

You will need a prescription from your healthcare provider in order to obtain Eflornithine cream. It is not available over the counter.

Q. Is Eflornithine an antibiotic?

Eflornithine is an irreversible enzyme inhibitor that is active primarily against several protozoan parasites. It inhibits ornithine decarboxylase in a manner that is detrimental to the parasites.

Q. Is Eflornithine cream permanent?

Topical Eflornithine is used to decrease facial hair in women. However, it does not eradicate face hair permanently or inhibit hair growth.

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