Atorvastatin Calcium (134523-03-8)

Atorvastatin Calcium Chemical Structure

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What is Atorvastatin Calcium

Atorvastatin calcium is an organic salt composed of calcium cations and Atorvastatin anions in a 1:2 ratio. Atorvastatin was first patented in 1986 and received FDA approval for medicinal use in 1996. It is listed as an essential medicine by the World Health Organization. It’s available as a brand-name drug called Lipitor but can also be purchased as a generic drug.

Atorvastatin acts by blocking HMG-CoA reductase, a liver enzyme involved in the production of cholesterol. It is a statin drug used to prevent cardiovascular disease and treat abnormal cholesterol levels in those who are at high risk. It is generally administered orally. The foetus may be harmed if used during pregnancy.

Macsen Laboratories is the supplier of high-quality Atorvastatin Calcium.
PRODUCT SPECIFICATIONS
Name of Product Atorvastatin Calcium
IUPAC Name calcium;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
Synonyms Lipitor; Sortis; Tahor; Atorvastatin Hemicalcium; Atorvastatin calcium salt
CAS No 134523-03-8
Molecular Formula C66H68CaF2N4O10
Molecular Weight 1155.3 g/mol
Pubchem CID 60822
Pubchem SID 463960353

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Color) White to off-white
2 Appearance (Form) Crystalline Powder
3 Solubility (in water) Practically Insoluble
4 Melting Point 198ºC
5 Solubility (in other solvents) Soluble in Methanol
6 Long term Storage 2-8ºC , dark

Uses

  • The primary use of the Atorvastatin calcium is for the treatment of Hypercholesterolemia and mixed Dyslipidemia to reduce total cholesterol, LDL-C, apo-B, triglycerides levels, and CRP as well as increase HDL levels.
  • It also helps in the primary prevention of heart attack and stroke and secondary prevention of myocardial infarctionstrokeunstable angina, and revascularization in people with established coronary artery disease. Atorvastatin helps to prevent cholesterol from building up in arteries in combination with therapy along with diet, weight loss, and exercise.
  • Myocardial infarction and stroke prevention in people with type 2 diabetes.

Side effects

The most prevalent adverse effects of Atorvastatin Calcium are:

  • Constipation
  • Diarrhoea
  • Nausea,
  • Fatigue,
  • Gas
  • Heartburn
  • Headache
  • Mild muscle pain

Serious side effects include:

  • Type 2 diabetes is observed in a small number of people
  • Muscle wasting and muscle breakdown (Rhabdomyolysis)
  • Confusion or memory problems
  • Liver Problems include dark urine, tiredness or weakness, loss of appetite and yellowing of the skin or eyes (Jaundice)

FAQs

Q. Is Atorvastatin Calcium a blood thinner?

No, Atorvastatin isn’t a blood thinner. It’s a statin drug that works to help improve cholesterol problems and lower your risk for heart-related problems.

Q. What is Atorvastatin Calcium good for?

Atorvastatin, when combined with a healthy diet, can help lower “bad” cholesterol and fats (such as LDL and triglycerides) while increasing “good” cholesterol (HDL). It belongs to the “statin” class of medications. It works by lowering the amount of cholesterol the liver produces.

Q. What foods should be avoided when taking atorvastatin?

As part of your overall treatment with atorvastatin, avoid high-fat and high-cholesterol foods. Large amounts of grapefruit or grapefruit juice should be avoided because they can cause dangerous negative effects. Also, excessive alcohol consumption might lead to major liver disorders.

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