Cefuroxime (55268-75-2)

Cefuroxime Chemical Structure

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What is Cefuroxime

Cefuroxime is a 3-(carbamoyloxymethyl)cephalosporin compound. It is a semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. It was approved for medical use in 1977. It is included in the World Health Organization’s List of Essential Medicines. The common brand names under which Cefuroxime is sold in various countries are Zinacef, Axim, Rofurox, Kilbac, Xorimax, Ceftum, Supacef, Zamur, etc.

It is an antibiotic and kills bacteria by preventing them from building the necessary bacterial protective coating (cell wall). It is used to treat and prevent several bacterial infections including pneumonia, meningitis, otitis media, sepsis, urinary tract infections, etc. It is also used to prevent infections after surgery.

Macsen Laboratories is the supplier of high-quality Cefuroxime.
PRODUCT SPECIFICATIONS
Name of Product Cefuroxime
IUPAC Name (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms Cephuroxime; Cefuroxim; Cefuroximo; Cefuroxima; Cefuroximum; Zinacef; Sharox; cefurossima; Céfuroxime
CAS No 55268-75-2
Molecular Formula C16H16N4O8S
Molecular Weight 424.4 g/mol
Pubchem CID 5479529
Pubchem SID 463960352

Technical Specifications

SR. No Criteria Limit/Specification
1 Appearance (Color) White to Light Yellow to Light Beige
2 Appearance (Form) Solid Powder or crystals
3 Solubility Freely soluble as sodium salt (145 mg/L)
4 Melting Point 218-225 °C
5 PURITY (HPLC AREA %) ≥ 95.0 %
6 WATER ≤ 3.0 %
7 Proton NMR Spectrum Conforms to Structure

Uses

  • Acute bacterial otitis media
  • Several upper respiratory tract infections
  • Bronchitis (infection of the airway tubes leading to the lungs)
  • Gonorrhoea (a sexually transmitted disease)
  • Lyme disease (an infection that may develop after a person is bitten by a tick)
  • Infections of the skin, ears, sinuses, throat, tonsils, and urinary tract

Side effects

Cefuroxime is generally well tolerated, and its side effects are usually transient. The common side effects are as follows:

  • Diarrhoea
  • Nausea
  • Vomiting
  • Headaches/migraines
  • Dizziness
  • Abdominal pain

Serious side effects may include:

FAQs

Q. What is Cefuroxime Axetil 500 mg used for?

Cefuroxime axetil is an acetoxyethyl ester prodrug of cefuroxime which is effective when taken by mouth. It is used to treat a wide variety of bacterial infections.

Q. How long does it take for Cefuroxime to work?

Cefuroxime is commonly prescribed for 5-10 days and should be taken every 12 hours, according to doctors. After taking the drug, it may take up to 48 hours for the symptoms to subside.

Q. Is Cefuroxime a penicillin?

Cefuroxime is a Cephalosporin antibiotic, chemically similar to Penicillin.

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