Fexofenadine hydrochloride (153439-40-8)

Fexofenadine hydrochloride Chemical Structure

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What is Fexofenadine hydrochloride

The hydrochloride salt derivative of fexofenadine, which has antihistaminic effect, is known as fexofenadine hydrochloride. It is a diarylmethane with long-lasting selective histamine H1 receptor antagonist. It is sold under the brand names like Allegra, Allegra-D, Mucinex Non-drowsy Allergy, Wal-fex, etc.

It was patented in 1979, but it wasn’t until 1996 that it was used in medical practice. It is included on the List of Essential Medicines published by the World Health Organization.

Macsen Laboratories is the supplier of high-quality Fexofenadine hydrochloride with ISO certification.
Name of Product Fexofenadine hydrochloride
IUPAC Name 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid;hydrochloride
Synonyms FEXOFENADINE HCL; Allegra; Telfast; Cloridrato de Fexofenadina; Fexofenadina cloridrato; Clorhidrato de fexofenadina; Chlorhydrate de fexofénadine
CAS No 153439-40-8
Molecular Formula C32H40ClNO4
Molar Mass 538.1 g/mol
Pubchem CID 63002
Pubchem SID 469688499

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) White to Beige
3 Solubility DMSO: soluble ≥5 mg/mL
4 Storage Temperature 20°C


  • Fexofenadine is recommended for the symptomatic treatment of allergic rhinitis (“hay fever“), including symptoms such as watery eyes, runny nose, itchy eyes/nose, sneezing, hives, and itching in patients ≥2 years old.
  • Additionally, it can be used to alleviate the symptoms of urticaria (hives; red, itchy raised areas of the skin) including itching and rash in adults and children 6 years of age and older.

Side effects

The common side effects associated with the use of fexofenadine hydrochloride are as follows:

  • Headache and dizziness
  • Back and muscle pain
  • Miosis or pinpoint pupils
  • Nausea & Vomiting
  • Menstrual cramps

Side effects of fexofenadine that are serious but less prevalent include the following:

  • Allergic reactions
  • Fever
  • Chills
  • Body aches
  • Cough
  • Other flu symptoms


Q. Can dogs take fexofenadine hydrochloride?

Fexofenadine hydrochloride is a second-generation antihistamine that can be used to treat itching and other symptoms of allergic diseases in dogs and cats.

Q. What does fexofenadine hydrochloride do?

Fexofenadine is a selective peripheral H1 receptor antagonist. It prevents the activation of the H1 receptors by histamine preventing the development of allergy-related symptoms.

Q. Does fexofenadine hydrochloride make you sleepy?

It is less common for fexofenadine to cause drowsiness in contrast to other antihistamines since it does not quickly penetrate the blood–brain barrier.

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