Fluconazole (86386-73-4)

Fluconazole Chemical Structure

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What is Fluconazole

The antifungal medication fluconazole, commonly known as Diflucan is a synthetic triazole and is used to treat both systemic and superficial fungal infections. It is given either by mouth or by injection into a vein.
It was patented in 1981 and came into commercial use in 1988 and got approved by the FDA in 1990. It is on the World Health Organization’s List of Essential Medicines.

Macsen Laboratories is the supplier of high-quality Fluconazole with ISO certification.
Name of Product Fluconazole
IUPAC Name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
Synonyms Diflucan; Triflucan; Biozolene; Elazor; Biocanol; Fluconazol; Fluconazolum; Flucostat; Zoltec; Fungata
CAS No 86386-73-4
Molecular Formula C13H12F2N6O
Molar Mass 306.27 g/mol
Pubchem CID 3365
Pubchem SID 469688498

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) White
3 Melting point 138-140 °C
4 Solubility Poorly soluble in water; Soluble in Organic solvents such as chloroform, propylene glycol


Fluconazole is used to prevent and treat a variety of fungal and yeast infections, like:
Vaginal yeast infections caused by Candida
• Certain systemic Candida infections of the bloodstream, kidney, or joints
• Esophageal and oropharyngeal candidiasis
Cryptococcal meningoencephalitis (central nervous system infection caused by fungus) and Peritonitis (inflammation of the peritoneum)
• In persons whose immune system has been impaired by cancer treatment, bone marrow transplant, or AIDS
Additionally, fluconazole is used to treat a specific kind of meningitis in HIV or AIDS patients.

Side effects

The common side effects associated with the use of Fluconazole are:
• Nausea, vomiting
• Diarrhea, stomach upset/pain
• Headache, dizziness
• Hair loss
Rare side effects include:
• Hypokalaemia
• Seizures
• Alopecia
Stevens–Johnson syndrome
• Hepatotoxicity including liver failure, anaphylactic/anaphylactoid reactions
Some serious side effects like liver problems, QT prolongation, and seizures may also occur.


Q. How long does it take for fluconazole to work?
Typically, it begins to work within a day, but it may take up to three days for your symptoms to improve and seven days for them to completely disappear.

Q. How long does fluconazole stay in your system?
The medicine fluconazole has a long half-life, and it will take our body more than a week (7 days) to metabolize the fluconazole.

Q. Is fluconazole an antibiotic?
Fluconazole is an antifungal medicine.

Q. Is Fluconazole FDA approved?
The U.S. Food and Drug Administration has approved fluconazole as a prescription antifungal medication (FDA).

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