Varenicline tartrate (375815-87-5)

Varenicline tartrate Chemical Structure

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What is Varenicline tartrate

Varenicline tartrate is a tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. Varenicline (brand names Chantix and Champix) is a smoking cessation medicine. Additionally, it is also used to treat dry eye condition. It is on the list of essential medicines maintained by the World Health Organization.

Macsen Laboratories is the supplier of high-quality Varenicline tartrate with ISO certification.
PRODUCT SPECIFICATIONS
Name of Product Varenicline tartrate
IUPAC Name (2R,3R)-2,3-dihydroxybutanedioic acid;5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene
Synonyms Champix; Chantix; Varenicline (Tartrate); Champix tartrate; varenicline monotartrate
CAS No 375815-87-5
Molecular Formula C17H19N3O6
Molar Mass 361.3 g/mol
Pubchem CID 9906942

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) White to Beige
3 Solubility DMSO: >5 mg/mL
4 Storage Temperature Room temp.

Mechanism of action

It has the potential to lessen the craving and withdrawal symptoms brought on by quitting smoking because it is a high-affinity partial agonist for the nicotinic acetylcholine receptor subtype (nACh) 42. When activated, nACh causes the release of the neurotransmitter dopamine in the nucleus accumbens reward centre of the brain.

Uses

Varenicline is an anti-smoking medication that works by preventing the effects of nicotine in the brain, which are responsible for the desire to smoke and is thus prescribed to adults who are attempting to quit the habit of smoking (smoking cessation).

Side effects

Common side effects associated with the use of Varenicline tartrate are:

  • Mild nausea, Vomiting
  • Headache, Drowsiness
  •  Flatulence, constipation
  • Trouble sleeping
  • Unusual dreams
  • Changes in taste

Serious side effects indicating immediate medical help include:

  • Seizure
  • Symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating)
  • Signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion)
  • Harmful behavior to self/others/property

FAQs

Q. How to store varenicline tartrate powder?

Varenicline tartrate needs to be stored at room temperature in a tightly closed container protected from light.

Q. Is varenicline the same as bupropion?

Wellbutrin (bupropion) is an antidepressant used for the management of major depression and seasonal affective disorder and Chantix (varenicline) is used for cessation of smoking. However, the Zyban brand of bupropion is used similarly to Chantix to help people stop smoking by reducing cravings and other withdrawal effects.

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