Selenious Acid Injection | Uses, side effects, Indication, dosage & brands

Selenious Acid Injection is a sterile solution that is prepared by dissolving selenium into nitric acid. In this article, we have covered what is selenious acid injection, its dosage, uses, side effects and injection brands.
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Selenious acid has the formula H2SeO4 and is an inorganic compound. It’s a selenium oxoacid whose structure is more precisely described as (HO)2SeO2. It’s a colourless substance and it is utilised in the manufacturing of glass and animal feeds. It is made by oxidizing lower-oxidation-state selenium compounds. A sterile solution of Selenious Acid Injection is prepared by dissolving selenium into nitric acid.

The oxidation of selenium dioxide with hydrogen peroxide is one method:

SeO2 + H2O2 → H2SeO4

Another way to make Selenious acid is to use chlorine to oxidize elemental selenium in a water suspension:
Se + 4 H2O + 3 Cl2 → H2SeO4 + 6 HCl

What is Selenious Acid Injection?

The usage of this Selenious Acid injection as a method of supplement to solutions for total parenteral nutrition is suggested. To avoid deficiency, selenious acid, which is included in TPN formulas, helps to maintain plasma selenium levels as well as endogenous storage. Anti-dandruff shampoos and seborrhea treatments contain selenium compounds, such as selenium sulfide. Selenite will be the focus of discussion for the sake of brevity, and more information about selenium can be found at Selenium.

Selenious Acid Injection Brands

Indications

When oral or enteral nutrition is not possible, insufficient, or contraindicated, Selenious Acid Injection is used as a source of selenium for parenteral nutrition in adults and children.

Selenious Acid Injection is a trace element that is used to give selenium for parenteral nutrition in adult and paediatric patients when oral or enteral nourishment is not practicable, inadequate, or contraindicated.

Because of the risk of infusion phlebitis, selenium injection should not be given undiluted by direct injection into a peripheral vein.

Dosage

Selenious Acid Injection contains 60 mcg/mL of selenium.

The dosage should be changed according to the patient’s condition, needs of nutrition, and contribution to enteral selenium consumption or oral. The dosages listed below are general recommendations for the majority of patients. Some patients, however, may require a higher dosage based on clinical needs:

  • 60 mcg/day for adults
  • 2 mcg/kg/day (up to 60 mcg/day) for pediatric patients weighing 7 kg and up
  • 2 to 4 mcg/kg/day for pediatric patients weighing less than 7 kg
  • During treatment, keep an eye on your selenium levels.

Selenium injection contains 40 mcg selenium/mL. The suggested additive dosage level for metabolically stable adults receiving TPN is 20 to 40 mcg selenium per day. The recommended additive dosage level for pediatric patients is 3 mcg/kg/day.

Selenium as selenomethionine or selenious acid, given intravenously at 100 mcg/day for 24 or 31 days in adults with selenium deficiency caused by long-term TPN support, has been shown to reverse deficiency symptoms without causing toxicity.

The addition of selenium to the TPN solution should be done aseptically in a laminar flow hood. The electrolytes and other trace elements found in the amino-acid/dextrose solution used for TPN are physically compatible with selenium. As a guideline for subsequent administration, frequent monitoring of plasma selenium levels is recommended. The normal range for selenium in whole blood is 10 to 37 mcg/100 mL.

Ascorbic acid injection should not be mixed with selenium-containing parenteral products in the same syringe or vial, as this could result in an insoluble precipitate.

When the solution and container allow, parenteral drug products should be visually inspected for particulate matter and discolouration.

Selenious Acid Injection uses

  • Glutathione peroxidase, which protects cells from oxidative damage caused by peroxidases produced during cellular metabolism, contains selenium.
  • Selenium is required for the proper functioning of the circulatory system. It also helps to maintain the health of the heart muscle and skin tissue. Because it stimulates antioxidant activity and protects cell membranes, it may also aid in cancer prevention.
  • Selenious acid aids in the preservation of vitamin E, which promotes cell antioxidant defence and is essential for tooth structure.
  • Humans with long-term TPN (total parenteral nutrition) support have developed selenium deficiency symptoms such as muscle pain and tenderness. The symptoms have been reported to improve when selenium is added to TPN solutions. Selenium,
  • Low dietary selenium intake has been linked to pediatric conditions, Keshan disease, and Kwashiorkor. The circumstances are only seen in places with low soil selenium levels. Supplementing with selenium salts in the diet has been shown to reduce the occurrence of these conditions in children.

How to use Selenious Acid Injection

Direct intravenous infusion of Selenious Acid Injection is not recommended. Selenious Acid Injection must be prepared and used as an admixture in parenteral nutrition solutions prior to administration.

Only a suitable work area, such as a laminar flow hood, should be used to prepare Selenious Acid Injection (or an equivalent clean air compounding area). It is vital in the preparation to apply a cautious aseptic approach to avoid unintended contact contamination during solution mixing and the addition of additional nutrients.

Visually evaluate the prepared parenteral nutrition solution containing Selenious Acid Injection for particle matter before admixing, after admixing, and before delivery.

  • Check for particulate matter in the Selenious Acid Injection Bulk Pharmacy Package.
  • Following the admixture of amino acids, dextrose, lipid (if added), and electrolytes solutions, add Selenious Acid Injection to the parenteral nutrition solution.
  • All additions to the parenteral nutrition container should be evaluated for compatibility and stability of the resulting preparation, as additives may be incompatible. If a pharmacist is available, speak with him or her. America Regent is the person to contact if you have any compatibility questions. Use the aseptic technique if it is deemed necessary to introduce additives to the parenteral nutrition container.
  • Check that the final parenteral nutrition containing Selenious Acid Injection fits the following requirements:
  1. There were no precipitates formed during the mixing or addition of additives.
  2. If lipids have been added, the emulsion has not separated. The accumulation of yellowish droplets in the admixed emulsion can be seen as a yellowish streaking, indicating emulsion separation.
  3. If there are any precipitates, toss them out.

Storage and handling

  • Only pierce the vial closure once with a suitable sterile transfer device or dispensing set that allows for precise content dispensing.
  • Use Selenious Acid Injection for admixing as soon as the sterile transfer set is inserted into the Pharmacy Bulk Package container or within 4 hours after the container closure has been penetrated at room temperature (25ºC/77ºF). Any remaining medication should be discarded.
  • After mixing, use the parenteral nutrition solution containing Selenious Acid Injection right away. Any admixture storage should be kept between 2°C to 8°C (36°F to 46°F) and for no more than 9 days. After removing the infusion from the refrigerator, use it right away and finish it within 24 hours. Any remaining admixture should be discarded.
  • The light should be kept away from the admixed parenteral nutrition solution.

Side Effects

Symptoms that necessitate immediate medical attention

Selenium can have some unfavourable side effects in addition to its beneficial effects. Although not all of these side effects are likely to occur, if they do, medical attention may be required. 

Symptoms of overdose

  • irritability
  • itching of skin
  • Diarrhoea
  • fingernail weakening
  • garlic odour of breath and sweat
  • hair loss
  • nausea and vomiting
  • unusual tiredness and weakness

Toxicity-High selenium dosages (15-30 mcg/egg) have been demonstrated to cause substantial embryological consequences in growing chickens. There are currently no studies in pregnant women that are adequate and well-controlled. Only use selenium acid injections during pregnancy if the potential benefits outweigh the risk to the developing fetus.

Oral ingestion of 5 to 10 grams of selenium has been linked to death due to circulatory collapse. Selenium concentrations in serum or blood have been observed to range from 190 mcg/dL to 3,800 mcg/dL in fatal instances.

Precautions

Pulmonary Embolism in the Presence of Pulmonary Vascular Precipitates: Stop the infusion and seek medical help if you notice signs of pulmonary distress.

Thrombosis and Vein Damage: A central venous catheter is required for solutions with an osmolarity of 900 mOsmol/L or higher.

Toxicity of Aluminum: Patients with renal impairment, including preterm infants, are at higher risk.

Laboratory tests and monitoring: Throughout treatment, keep track of selenium levels, fluid and electrolyte status, serum osmolarity, blood glucose, liver and kidney function, blood count, and coagulation parameters.

FAQs

Q1. Is Selenium the same as Selenious acid?

Answer-The acid form of sodium selenite, a form of selenium, is selenious acid. Selenium is a trace element that also serves as an antioxidant. It regulates cofactor metabolic enzymes. It also has antioxidant properties and plays an important role in maintaining the general health of tissue and muscle.

Q2.Is Selenious acid strong?

Answer-Selenic acid, like sulfuric acid, is a strong acid that is hygroscopic and water-soluble.

Disclaimer-

The information provided here is based on general knowledge, articles, research publications etc and we do not claim the authenticity of any of the information provided above. We do not claim or suggest/advise any medical, therapeutic, health or nutritional benefits of SA. We do not supply or promote our SA product for the applications which are covered by valid patents and which are not approved by the FDA.

Macsen Labs is a manufacturer and supplier of several grades of Selenious acid such as:-

 

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