Custom Synthesis
Macsen Labs is one of the few companies that has gained expertise in Organic & Inorganic chemical synthesis from lab to plant scale, through the years of experience in developing our own products.
Now, our expertise is open for synthesizing Organic & Inorganic chemical compounds as per customer requirements. Our company can support your temporary/regular requirements, research and product development by offering our custom chemical synthesis services.
We can synthesize Organic & Inorganic compounds from milligrams to tons involving different kinds of chemistries, reaction conditions, processes, and isolation & purification techniques. We can very well handle hazardous chemicals and perform hazardous chemistry in a safe manner.
Our Areas of Expertise Include:
Optimization of synthetic process of organic compounds.
Development of cost-effective and eco-friendly process.
To investigate the designed route for feasibility. Optimization of process for more cost effectiveness.
Screening of patent databases for non-infringement of selected routes, compound purity and polymorphic forms.
Synthesis of impurities and their characterization by methods like LCMS HPLC, IR, NMR and GC.
Literature search and designing cost effective and novel, scalable, safe synthetic route. We have access to best retro-synthesis software for fast and efficient screening of synthesis routes & starting materials and building blocks availability and cost.
Literature search and designing cost effective and novel, scalable, safe synthetic route. We have access to best retro-synthesis software for fast and efficient screening of synthesis routes & starting materials and building blocks availability and cost.
Our scientists are experienced in chemical conversions like heterocyclic chemistry, metal mediated synthesis, reductive amination, reductions, oxidations, cyanation, chlorination, nitration, Friedel-Crafts reactions, C, O, N-alkylations, chiral resolutions and many more.
Our scientists are experienced in chemical conversions like heterocyclic chemistry, metal mediated synthesis, reductive amination, reductions, oxidations, cyanation, chlorination, nitration, Friedel-Crafts reactions, C, O, N-alkylations, chiral resolutions and many more.
Rights involved in the process and information shared by you, as well as during development of your product/process in our R&D lab. We can also assist you to identify and protect your intellectual property rights in form of provisional patents and final patent applications, with help of our in-house IP team and reputed IP Attorneys.
Analytical Capabilities & Quality Control
We, being a cGMP API manufacturer have an edge in the Analysis and Quality Control because of our expertise in compliance of GLP practices, Analytical Method Development, method validation, etc. We can develop and validate accurate, precise and robust analytical methods for the synthesized compounds.
Our in-house high-tech sophisticated analytical instrumentation facility having instruments like LC-MS/MS, GC-MS/MS, ICP-OES, FTIR, HPLC etc. enable us to perform difficult chemistries & prepare high purity compounds with very less turnaround time.
We have tie ups with other sophisticated instrumentation facilities for analytical services like NMR, XRD, SEM, TEM, etc.
What makes us stand apart?
Quick product development, Fast Response, Focus on cost optimization, Full confidentiality through Non-Disclosure and Confidentiality Agreements are some of the key factors which makes us stand apart. Our highly optimized way of functioning and efficient purchase mechanisms enables us to offer you high class services at much lower costs than other organizations.
Reactions we have experience in handling and performing:
Halogenation reactions like Chlorination, Bromination etc
Condensation Reactions
Reduction reactions like hydrogenation using palladium or nickel catalyst and using reducing reagents
Oxidation Reactions
Cyclisation Reactions
Coupling Reactions etc.
Handle oxidizing, reducing, pyrophoric reagents
Chiral Synthesis
Infrastructure in R&D / Gram scale Lab:
- Bench Top and Walk-in fume hoods.
- All types of reaction assemblies and apparatus in glass.
- S.S 316L 2 Litre Autoclave for high pressure reactions and hydrogenation.
- Rotary Evaporators
- Vacuum Dryers, Ovens, Bench Top Centrifuge, High Vacuum Diaphragm Pumps, Magnetic stirrer, Overhead stirrer, etc.
- All utilities like Vacuum, Nitrogen, Chilled Water, etc.
- For impurity/product isolation: column chromatography (combi flash) & preparative HPLC.
Infrastructure in Kilo Lab:
- Complete Reaction Assemblies in glass from 50 litre till 300 Litre vessel capacity.
- All utilities like Vacuum, Nitrogen, Chiller, Steam, Thermic Fluid, etc.
- Separation equipment like centrifuge, vacuum nutsche, etc.
- Vacuum dryer & Tray Dryer.
Infrastructure at plant scale:
- Reaction vessels in S.S 316L & GLRs upto 5000 Litres.
- All utilities like Vacuum, Nitrogen, Air, Steam, Chiller, Thermic Fluid, etc.
- Separation equipments like centrifuge, Nutsche Filter, ANFD, etc.
- Vacuum Dryer, Tray Dryer, Fluid Bed Dryer, etc.
FAQs
Q. What is Custom Synthesis?
During the process of Custom synthesis, a company or an individual customer makes a request for a molecule to be manufactured exclusively for them at a particular scale, with the purity, and utilising the specifications or techniques that they have specified.
Q. How is Custom Synthesis important?
Custom synthesis is one of the options that is available to drug developers who are in need of active pharmaceutical ingredients (APIs) or other organic or inorganic chemicals to make their products effective when it is impossible or impractical for them to make these molecules and compounds in-house. It is prudent to give some thought to the possibility of contracting out the production of a product to industry experts who concentrate their practice in the relevant field.
Q. When I call for a price quote, what kind of information should I have ready?
In general, the answer to this question is that you should give as much information as you can. The more specific you are with your request, the more accurately we will be able to quote you and fulfil your needs. In general, we would require the following information, however this is only a rough indication:
- Product Name
- Molecular Formula, CAS No. (if known)
- Quantity Required
- Application
- Any references to publication or literature references (if available)
- Reaction Scheme
Q. How do we proceed with your request?
We check for the feasibility of your requested molecule/compound, followed by providing you with a quote complemented by a synthetic scheme.