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What is Silver Sulfadiazine Cream | Brands, Uses and More

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What is Silver Sulfadiazine Cream?

Silver Sulfadiazine Cream is an antibiotic medication used to treat wounds, skin infections, and second-third-degree burns. It kills harmful bacteria and relieves inflammatory symptoms including burning, itchiness, and pain. Treatment with silver sulfadiazine for burns and wounds is beneficial.

Reference for the above >>> SILVADENE

Silver Sulfadiazine Cream Brands

Silver Sulfadiazine Cream Uses

In patients with severe burns, this medicine is used in combination with other therapies to help prevent and cure wound infections. Microorganisms that may infect an open wound are inhibited by silver sulfadiazine. This decreases the risk of the bacteria spreading to nearby skin or the bloodstream, where it might cause a serious blood infection.

How to apply Silver Sulfadiazine cream?

The medication should not be used in greater or lesser doses or for longer than prescribed.  When administering silver sulfadiazine to burn wounds, it is essential to use sterile disposable gloves. The infected area should be kept as clean as possible to prevent additional infection.

The infected area should be cleansed as advised by the doctor. Apply a sufficient amount of silver sulfadiazine to the affected area and cover it evenly. This drug should be applied in a 1.6 mm thick layer that is one-sixteenth (1/16) of an inch thick.

Apply extra cream as needed to replace any other medication that has gotten on bandages, clothes, or bed linens. After showering or using a water treatment, reapply the cream.

Silver sulfadiazine cream is typically administered once or twice daily. This medication must be applied to burn wounds in a way that the affected area is entirely covered with the cream. Skin that has been treated can be left exposed, or a gauze bandage can be used if prescribed by the doctor.

What happens when a dose is missed?

Skipping any doses will raise the chances of contracting other antibiotic-resistant infections. As soon as you remember, take the missed dosage. If the next dosage is approaching, skip the missing dose and resume your usual dosing regimen. Do not take a doubled dosage to compensate for a missing one. The burn wounds should always be coated with silver sulfadiazine cream to prevent any infections.

Things to care about while using Silver Sulfadiazine ointment

The cream should be used only in the amount that has been prescribed by the doctor. It is necessary to wash the hands before applying the cream. All the instructions mentioned on the packaging should be strictly followed. This will only raise the risk of adverse repercussions. Any contact with the eyes, nose, or mouth should be avoided. If the medication gets in these places by accident, rinse it with water. This medication should not be given to infants under the age of two months.

The existence of other medical issues may have an impact on the use of this medication. Make careful to inform your physician if you have any other health conditions, particularly:

Use with precaution if you have glucose-6-phosphate dehydrogenase (G6PD) insufficiency (a genetic metabolic condition affecting red blood cells). Patients with this syndrome may experience blood issues.

Use with care if you have kidney or liver illness. Because the drug is removed from the body more slowly, the effects may be amplified.

Porphyria—Use of this medication may cause a severe case of porphyria.

It is critical that your doctor monitors your development on a frequent basis. This will help the doctor to determine if the medication is working well and to look for any issues or side effects that may have been caused by it. Consult the doctor if your skin infection or burn does not heal within a few days or weeks, or if it worsens. Do not use this medication to treat a skin condition that has not been evaluated by a doctor.

Side effects of Silver Sulfadiazine Cream

Some adverse effects may develop that might not necessitate medical treatment. These adverse effects may subside as your body responds to the medication. Additionally, your healthcare provider should advise you on how to avoid or mitigate some of these adverse effects. Consult the doctor if any of the following side effects persist or become troublesome or if you have any concerns about them.

Using silver sulfadiazine can have various side effects ranging from mild to severe. Hives, swelling of face, lips, tongue, throat and difficulty in breathing are some of the most common side effects.

Although the chance of significant adverse effects is low when the skin comes in contact with silver sulfadiazine, if the drug is taken into the blood circulation, negative side effects can occur.

You should call your doctor if you face any of the severe side effects given below;

  1. A sudden feeling of fatigue, fever, soreness in mouth and throat, chills, swollen gums and difficulty in eating and swallowing anything;
  2. Skin becoming easily perceptible to bruising, unusual vaginal or anal bleeding, spotting under skin particularly purple or red in colour;
  3. Discolouration of urine, problem in urinating, weight gain;
  4. Skin rashes and blisters particularly pink and purple coloured and pain in the upper abdomen.

Visit your physician immediately if you experience blistering, peeling, red skin lesions, severe acne, skin rashes or ulcers, or fever or chills while using this medication. Inform the medical doctor in charge of any medical testing that you are taking this medication. This medication may have an effect on the results of some tests.

Interaction of Silver Sulfadiazine cream with other drugs

Other medications, including prescribed and over-the-counter medications, vitamins, and herbal supplements, might interact with silver sulfadiazine. Specific drugs should not be taken or when consuming certain types of food, since complications may occur. Using alcohol or smoking in conjunction with some medications may also result in abnormalities. Inform all of your healthcare providers about all of the medications you are currently taking, as well as any new or discontinued medications. Discuss the use of the medicine with your healthcare provider.

Storage and other things to keep in mind

  1. Keep the medication in a tightly sealed container at room temperature, away from moisture, heat and direct sunlight. Prevent it from freezing.
  2. Keep out of children’s reach.
  3. Do not store out-of-date or no-longer-needed medications.
  4. Take guidance from your healthcare provider about how to dispose of the medications that are not needed further.

Macsen Laboratories Manufactures Silver Sulfadiazine API which is used in a final formulation like Silvadene and Flamazine suitable for burns and scars.


Q. Can silver sulfadiazine cream be used for acne and scars?

Unlike harsher treatments such as retinoids, antibiotics, and benzoyl peroxide, silver looks to be particularly favorable for use as an acne treatment due to its low risk of bacterial resistance, absence of irritation, and ability to preserve the skin barrier.

Q. Can you use too much silver sulfadiazine cream?

Your burn wounds should always be coated with silver sulfadiazine cream. An overdose of silver sulfadiazine cream is unlikely to be harmful.

Q. Can you use silver sulfadiazine cream on dogs?

Silver Sulfadiazine Cream 1% is a topical antibacterial cream that can be used on cats, dogs, and horses to provide relief from itching throughout the healing process, prevent infection, and shorten the amount of time it takes for the wound to heal. However, it should not be used on animals who have an allergy to Sulphur or sulfa medications, on animals that are pregnant or nursing, and it should only be administered on the skin of the animal.

Q. How is silver sulfadiazine cream for radiation burns?

In a study, Silver Sulfadiazine cream was found to minimize the severity of radiation-induced skin harm in comparison to general skin care alone.

Q. When should I stop using silver sulfadiazine cream?

You can stop using the medication when your burn wound has healed completely.

Q. Does silver sulfadiazine promote healing?

It works by killing bacteria and preventing them from spreading further infection. It is an antibiotic and hence it promotes skin healing.

Q. Why can’t Silver Sulfadiazine cream be used on the face?

This medication should only be used to treat burnt skin and wounds and should not be used on the face.

Q. Does Silver Sulfadiazine cream delay wound healing?

Negative-pressure wound treatment quickens the healing of polluted wounds, especially when silver is administered as a supplement. Silver sulfadiazine delays recovery and shouldn’t be used on burns.

Q. Can silver sulfadiazine cream be used for rash?

Silver Sulfadiazine Cream is effective at preventing infection in burn wounds and small skin grafts. Use in superficial rashes is generally not preferred.

Q. Can silver sulfadiazine cream be used for boils?

Cream containing silver sulfadiazine is of no use in treating boils.

Q. What does silver sulfadiazine cream do?

Antibiotic properties can be found in silver sulfadiazine. It achieves its effect either by eliminating the bacteria or by inhibiting their ability to reproduce.

Q. Does silver sulfadiazine cream expire?

Always make sure to use the product before the expiration date that is printed on the label. The cream containing silver sulfadiazine must be stored at room temperature and away from moisture at all times.

Q. Can silver sulfadiazine cream be used for sunburn?

Patients who suffer from severe sunburns, particularly those accompanied by blistering, should be instructed to apply 1% silver sulfadiazine twice day (including after showering). Patients have reported experiencing less discomfort and quicker recovery times. Before providing this treatment, it is important to check for any allergic reactions to medications.

Q. Can silver sulfadiazine cream be used for athlete’s foot?

You can use silver sulfadiazine cream to treat infected leg ulcers or pressure sores, and it can also be used to prevent skin infections that result from burns.

Q. Can you buy silver sulfadiazine cream over the counter (OTC)?

Silver Sulfadiazine cream can not be bought over the counter. You will need a prescription from your healthcare provider in order to obtain it.

Q. Does silver sulfadiazine cream burn?

It’s possible that the treated skin will experience pain, burning, or itching.

Q. How is silver sulfadiazine cream for yeast infection?

Silver sulfadiazine possesses extensive antibacterial action. It is bactericidal against numerous gram-negative and gram-positive bacteria as well as yeast.


The information provided here is based on general knowledge, articles, research publications etc and we do not claim the authenticity of any of the information provided above. We do not claim or suggest/advise any medical, therapeutic, health or nutritional benefits of SSD. We do not supply or promote our SSD product for the applications which are covered by valid patents and which are not approved by the FDA.

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