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Atovaquone (95233-18-4)

Atovaquone Chemical Structure

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What is Atovaquone

Atovaquone is a synthetic naphthoquinone compound with antiprotozoal activity. It is a yellow crystalline solid that is practically insoluble in water. It is sold under the brand name Mepron (oral suspension) and is generally used for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP).

Macsen Laboratories is the supplier of high-quality Atovaquone with ISO certification.
Name of Product Atovaquone
IUPAC Name 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione
Synonyms Mepron; Wellvone; Acuvel; cis-Atovaquone; Atovaquona; atovacuona;
CAS No 95233-18-4
Molecular Formula C22H19ClO3
Molar Mass 366.8 g/mol
Pubchem CID 74989
Pubchem SID 469688495

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) Yellow
3 Melting point 216-219 °C
4 Storage temp. 2 to 8 °C, dark

Mechanism of action

Atovaquone is a competitive inhibitor of ubiquinol and blocks the mitochondrial electron transport at complex III ( bc1 complex) of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death.


Atovaquone is used to prevent and treat:

Side effects

Common side effects include:

  • Nausea & Vomiting
  • Diarrhoea
  • Dizziness/Headache
  • Anxiety
  • Difficulty falling asleep or staying asleep
  • Runny nose

Serious side effects include:

  • Rash
  • Fever
  • Swelling of the eyes, face, lips, tongue, mouth, or throat
  • Hives
  • Difficulty breathing or swallowing
  • Hoarseness or throat tightness


Q. What is atovaquone-proguanil used for?

Atovaquone and proguanil is a combination medicine used to treat or prevent malaria. It is effective against drug-sensitive and drug-resistant P. falciparum. It is also used to prevent malaria infection in travellers who visit areas where malaria is common.

Q. Is atovaquone an antibiotic?

Atovaquone is an antibiotic. It is an antiprotozoal agent.

Q. Does atovaquone treat Covid?

Atovaquone has been shown in a preliminary study to prevent SARS-CoV-2 replication in vitro. Atovaquone is now undergoing clinical studies in the United States (since December 2021) for the treatment of COVID-19.

Q. How long does atovaquone stay in your system?

The elimination half-life of atovaquone is about 2 to 3 days in adult patients.

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