Atovaquone is a synthetic naphthoquinone compound with antiprotozoal activity. It is a yellow crystalline solid that is practically insoluble in water. It is sold under the brand name Mepron (oral suspension) and is generally used for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP).
|Name of Product||Atovaquone|
|Synonyms||Mepron; Wellvone; Acuvel; cis-Atovaquone; Atovaquona; atovacuona;|
|Molar Mass||366.8 g/mol|
|1||Appearance (Form)||Solid Powder|
|3||Melting point||216-219 °C|
|4||Storage temp.||2 to 8 °C, dark|
Atovaquone is a competitive inhibitor of ubiquinol and blocks the mitochondrial electron transport at complex III ( bc1 complex) of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death.
Atovaquone is used to prevent and treat:
Common side effects include:
Serious side effects include:
Q. What is atovaquone-proguanil used for?
Atovaquone and proguanil is a combination medicine used to treat or prevent malaria. It is effective against drug-sensitive and drug-resistant P. falciparum. It is also used to prevent malaria infection in travellers who visit areas where malaria is common.
Q. Is atovaquone an antibiotic?
Atovaquone is an antibiotic. It is an antiprotozoal agent.
Q. Does atovaquone treat Covid?
Atovaquone has been shown in a preliminary study to prevent SARS-CoV-2 replication in vitro. Atovaquone is now undergoing clinical studies in the United States (since December 2021) for the treatment of COVID-19.
Q. How long does atovaquone stay in your system?
The elimination half-life of atovaquone is about 2 to 3 days in adult patients.
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