Pantoprazole Sodium (138786-67-1)

Pantoprazole sodium Chemical Structure

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What is Pantoprazole Sodium

Pantoprazole sodium, marketed under the name Protonix, is an organic sodium salt of Pantoprazole. It is a first-generation proton pump inhibitor that brings about a reduction in the amount of acid that is produced in the stomach.

It came into medical use in Germany in 1994. Pantoprazole can be taken orally in the form of either a tablet or a liquid suspension, or it can be administered intravenously (IV). It is available as a generic medication.

Macsen Laboratories is the supplier of high-quality Pantoprazole sodium with ISO certification.
Name of Product Pantoprazole Sodium
IUPAC Name sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
Synonyms Pantoloc; Protonix; Pantecta; Protium; Zurcal; PANTOPRAZOLE SODIUM SALT
CAS No 138786-67-1
Molecular Formula C16H14F2N3NaO4S
Molar Mass 405.4 g/mol
Other available variants Pantoprazole Sodium Sesquihydrate (164579-32-2)
Pubchem CID 15008962
Pubchem SID 469688500

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) White
3 Melting point (DSC) 156 °C
4 Storage Temperature 2 to 8 °C, dark

Mechanism of Action

Pantoprazole is a proton pump inhibitor (PPI). It binds to the sulfhydryl group of H+, K+-ATPase, an enzyme responsible for speeding the final step in the acid secretion route. The inactivation of the enzyme inhibits stomach acid output, which in turn relieves acid-related indigestion and heartburn.


  • Pantoprazole is used for short-term treatment of the symptoms of esophagitis (erosion and ulceration of the oesophagus) caused by stomach acid due to gastroesophageal reflux disease for adults and children five years of age and older.
  • It may sometimes be combined with antibiotics to treat Helicobacter pylori-caused ulcers.
  • It is also used to treat Zollinger-Ellison syndrome (pathological hypersecretory condition).
  • It may be used to prevent gastric ulcers in those taking NSAIDs.

Side effects

The common side effects associated with the use of Pantoprazole are as follows:

  • Diarrhoea
  • Flatulence
  • Dizziness, Headache
  • Nausea, Vomiting,
  • Abdominal pain
  • Joint pain
  • Injection site reaction

Serious and long-term side effects include:


Q. What is Pantoprazole sodium 40 mg used for?

Pantoprazole is a medication that is taken to treat the damage caused by gastroesophageal reflux disease (GERD).

Q. How long does it take for pantoprazole sodium to work?

Within 2-3 days, you should start to feel better. It is possible that you will continue to have some of your symptoms until the pantoprazole fully takes effect, which could take up to four weeks.

Q. Does pantoprazole sodium cause weight gain?

It is possible for you to see a rise in weight while you are taking pantoprazole oral tablets.

Q. Is pantoprazole sodium an antacid?

The proton pump inhibitor, pantoprazole, lowers the quantity of acid that is produced by your stomach.

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