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Phenazopyridine hydrochloride (136-40-3)

Phenazopyridine hydrochloride Chemical Structure

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What is Phenazopyridine hydrochloride

Phenazopyridine hydrochloride is formed by reacting phenazopyridine(1+) with one equivalent of hydrochloric acid. It is a synthetic, brick-red crystalline solid with a local anesthetic and topical analgesic effect on mucosa lining of the urinary tract.

Phenazopyridine is an azo dye that was discovered by Bernhard Joos, the founder of Cilag.  It is reasonably anticipated to be a human carcinogen.

Macsen Laboratories is the supplier of high-quality Phenazopyridine hydrochloride with ISO certification.
Name of Product Phenazopyridine hydrochloride
IUPAC Name 3-phenyldiazenylpyridine-2,6-diamine;hydrochloride
Synonyms Phenazopyridine HCl; Pyridium; Urodine; 3-Phenylazo-2,6-diaminopyridine hydrochloride; Pyripyridium; Bisteril; Diridone; Mallophene; Suladyne; Azomine; Sedural
CAS No 136-40-3
Molecular Formula C11H11N5.ClH
Molar Mass 249.70 g/mol
Pubchem CID 8691
Pubchem SID 470087775

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) Brick-red microcrystals with a slight violet luster or a purple powder
3 Taste Slightly bitter taste
4 Solubility Soluble in boiling water, acetic acid, glycerol, ethylene glycol and propylene glycol
Slightly soluble in cold water and ethanol
5 Melting Point 282 °F
6 Storage temp. 2-8°C


  • Phenazopyridine hydrochloride is used to alleviate urinary tract irritation-related symptoms, such as pain, burning, and the urgent or frequent need to urinate.
  • It is frequently administered following urethral, prostate, or urinary bladder surgery, which may irritate the epithelial lining of the urinary tract, as well as after endoscopic (cystoscopy) operations and the insertion of an indwelling Foley catheter.

Side effects

Side effects associated with the use of Phenazopyridine hydrochloride are:

  • Vivid color change in urine
  • little or no urination
  • swelling
  • rapid weight gain
  • confusion
  • loss of appetite
  • pain in your side or lower back
  • fever
  • pale or yellowed skin
  • stomach pain
  • nausea
  • vomiting
  • blue or purple appearance of your skin

It has been reported to cause methemoglobinemia and sulfhemoglobinemia after overdose and even at normal doses (in some cases).

Phenazopyridine should be avoided by people with glucose-6-phosphate dehydrogenase deficiency due to the risk of hemolysis.


Q. Does phenazopyridine hydrochloride cause cancer?

On the basis of substantial evidence of carcinogenicity gathered from research conducted on experimental animals, phenazopyridine hydrochloride can be expected to have a carcinogenic effect on human beings.

Q. Does phenazopyridine hydrochloride affect birth control?

This medication may reduce the efficacy of hormonal contraceptives such as the pill, patch, or ring and may result in pregnancy.

Q. How does phenazopyridine hydrochloride work?

Phenazopyridine HCl is eliminated in the urine, where it exerts analgesic effects on the urinary tract mucosa. This action relieves discomfort, burning, urgency, and frequency.

Q. Is phenazopyridine hydrochloride an antibiotic?

Phenazopyridine hydrochloride is not an antibiotic.

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