|Name of Product||Prilocaine|
|Synonyms||Propitocaine; Citanest; Prilocainum; prilocaine base; N-(2-Methylphenyl)-2-(propylamino)propanamide; Astra 1515; o-Methyl-2-propylaminopropionanilide; Prilocaina|
|Molar Mass||220.31 g/mol|
|4||Taste||Initially acid & then bitter taste|
|5||Melting point||37-38 °C|
|6||Solubility|| Freely soluble in alcohol
Slightly soluble in Chloroform
Practically insoluble in Ether
|7||Stability/Shelf life||Stable in Light & Air|
By preferentially binding to and preventing depolarization of the voltage-gated sodium channel, prilocaine stabilises the neuronal membrane. As a result, the membrane’s permeability is reduced, which in turn inhibits the ionic sodium inflow necessary for impulse initiation and conduction.
Common side effects of lidocaine include:
Serious side effects of lidocaine include:
Prilocaine causes less neurological and cardiac toxicity than other amide local anaesthetics but is associated with the potential of causing methemoglobinemia.
Q. What is lidocaine and prilocaine cream used for?
Lidocaine and prilocaine topical cream is used on the skin or in the genital area to cause numbness or loss of feeling before certain medical procedures. It is also used to prevent pain caused by an injection, the drawing of blood from a vein, or minor surgeries such as removing warts.
Q. What is the difference between prilocaine and lidocaine?
Prilocaine is an analogue of lidocaine that is a secondary amide, and it has a longer duration of action in addition to a rapid onset.
Q. Is prilocaine the same as novocaine?
The name “novocaine” is often used to denote several forms of local anaesthetic, such as Xylocaine (lidocaine ), Citanest (prilocaine ), or Septocaine (articaine ).
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