Telmisartan (144701-48-4)

Telmisartan Chemical Structure

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What is Telmisartan

Telmisartan is a benzimidazole derivative that is used to treat high blood pressure, heart failure, and diabetic kidney disease.Telmisartan/hydrochlorothiazide, Telmisartan/cilnidipine, and Telmisartan/amlodipine combinations are the different available marketed versions. It’s available as tablets of strength 20 mg, 40 mg, and 80 mg and is consumed orally.

It is offered under the brand names Micardis and others. It is an acceptable first-line therapy for hypertension. It was first used in medicine in 1999 after being patented in 1991.

Macsen Laboratories is the supplier of high-quality Telmisartan.
PRODUCT SPECIFICATIONS
Name of Product Telmisartan
IUPAC Name 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid
Synonyms Micardis; Pritor; Kinzalmono; Semintra; Telmisartana; Telmisartán
CAS No 144701-48-4
Molecular Formula C33H30N4O2
Molar Mass 514.6 g/mol
Pubchem CID 65999

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid
2 Appearance (Colour) White to slightly yellowish
3 Melting Point 261-263 °C
4 Solubility Practically insoluble in water, Sparingly soluble in strong acid (except insoluble in hydrochloric acid) and Soluble in strong base

Mode of Action

It has antihypertensive properties and is a non-peptide angiotensin II receptor antagonist. The AT1 subtype receptor, which is found in the smooth muscle of blood vessels and the adrenal gland, is specifically blocked by telmisartan. The antagonistic effect causes vasodilation and inhibits angiotensin II’s role in the production of aldosterone, which in turn causes a drop in salt and water retention as well as an increase in potassium excretion, which in turn lowers blood pressure.

Uses

  • Telmisartan treats high blood pressure (hypertension), thus helping in preventing stroke, heart attack and heart failure.
  • It is used to treat Diabetic Kidney disease.
  • For individuals over the age of 55 who have risk factors for severe heart conditions, telmisartan is also used to lower the chance of stroke, heart attack, or death from heart problems.

Side effects

Common side effects are as follows:

  • Flu-like symptoms
  • Dizziness, headache
  • Nausea, fatigue
  • Diarrhoea
  • Sinus pain and congestion
  • Back pain

Serious side effects are as follows:

  • Angioedema
  • Low blood pressure
  • Kidney problems
  • Allergic reactions
  • Tachycardia or Bradycardia (fast or slow heartbeat)
  • Oedema (swelling of hands, legs, tongue, throat or lips)

FAQs

Q. How long does it take for Telmisartan to work?

Telmisartan manages hypertension but does not cure it. During the first two weeks of your medication, your blood pressure may drop, but it can take 4-8 weeks before you get telmisartan’s full benefits. Despite feeling fine, keep taking telmisartan.

Q. When to take Telmisartan?

Telmisartan should be used only once a day, in the morning or evening. It’s a good idea to take it at the same time every day so you don’t forget.

Q. Is telmisartan a beta-blocker?

Telmisartan is a medication that blocks angiotensin receptors in the body (ARB). It achieves this by inhibiting the action of the chemical angiotensin, which in turn relaxes the arteries in the body.

Q. What is the difference between losartan and telmisartan?

Both Telmisartan and Losartan belong to the class of Angiotensin Receptor Blockers (ARB). However, Telmisartan has a longer duration of action. Given once daily, telmisartan 80 mg significantly decreased 24-hour blood pressure compared to losartan 50 mg, with the greatest benefit occurring in the last 6 hours of the dosage interval.

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