Tenofovir Disoproxil Fumarate (202138-50-9)

Tenofovir Disoproxil Fumarate Chemical Structure

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What is Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate is an adenine analogue. It is a prescription medicine approved by the U.S. Food and Drug Administration (FDA). It is sold under the trade name Videar among others and is generally used with other antiretrovirals to treat chronic hepatitis B and to prevent and treat HIV/AIDS. It is available in combinations such as  emtricitabine/tenofovirefavirenz/emtricitabine/tenofovir, and elvitegravir/cobicistat/emtricitabine/tenofovir.

Tenofovir was licensed for use in the United States in 2001 after being patented in 1996. It is listed as an essential medicine by the World Health Organization. As of 2017, it is available as a generic drug in the United States.

Macsen Laboratories is the supplier of high-quality Tenofovir Disoproxil Fumarate with ISO certification.
Name of Product Tenofovir Disoproxil Fumarate
IUPAC Name [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;but-2-enedioic acid
Synonyms Fumarato de Tenofovir Desoproxila; Tenofovir disoproxil fumarato; Fumarato de disoproxilo de tenofovir; Fumarate de ténofovir disoproxil
CAS No 202138-50-9
Molecular Formula C23H34N5O14P
Molecular Weight 635.5 g/mol
Pubchem CID 5486830

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Color) White
2 Appearance (Form) Fine, powder-like crystals
3 Solubility (in water) 13.4 mg/mL at 25 °C
4 Melting Point 115ºC
5 Long term Storage 2-8ºC , dark


  • Tenofovir disoproxil is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in patients ≥2 years old and weighing ≥10 kg.
  • Tenofovir is prescribed for chronic hepatitis B patients who are 12 years of age or older.
  • Furthermore, tenofovir disoproxil is available in conjunction with emtricitabine (under the brand name Truvada) for use as pre-exposure prophylaxis (PrEP) in at-risk adults and adolescents weighing more than 35kg to minimise the risk of sexually-transmitted HIV-1 infection.

Side effects

The most common side effects associated with the usage of tenofovir disoproxil are:

  • Dizziness
  • Nausea
  • Diarrhoea
  • Depression
  • Sleep disturbances
  • Headache
  • Itching and rash
  • Fever

Long term usage side effects include:


Q. When is the best time to take tenofovir disoproxil fumarate?

Tenofovir pills should be taken with a meal or snack.

Q. Does tenofovir cause liver damage?

Tenofovir does not appear to be a substantial contributor to liver harm caused by drugs.

Q. How long does it take for tenofovir to work?

When administered in combination with other antiretrovirals, tenofovir usually begins to function within the first four weeks, resulting in a substantial reduction in HIV viral load (amount of HIV virus in your blood). The viral load in a vast proportion of patients reduces to undetectable levels within three to six months.

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