Triclabendazole (68786-66-3)

Triclabendazole Chemical Structure

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What is Triclabendazole

Triclabendazole is a member of the benzimidazole family of anthelmintics with a chlorinated benzene ring but no carbamate group. In 2019, the United States Food and Drug Administration gave its approval for medical use of triclabendazole, currently being the only FDA-approved drug for individuals with fascioliasis. It is included on the List of Essential Medicines maintained by the World Health Organization.

Macsen Laboratories is the supplier of high-quality Triclabendazole with ISO certification.
PRODUCT SPECIFICATIONS
Name of Product Triclabendazole
IUPAC Name 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole
Synonyms Fasinex; Triclabendazol; Egaten; Triclabendazolum;
CAS No 68786-66-3
Molecular Formula C14H9Cl3N2OS
Molar Mass 359.7 g/mol
Pubchem CID 50248

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) White to Off-white
3 Melting Point 189-191°C
4 LogP 3.48
5 Storage Temperature 20°C ± 4°C

Uses

Triclabendazole find its use in both human and animal associated parasitic infections.

  • Triclabendazole is used in animals to treat Fascioliasis, a parasitic infection often caused by the helminth, Fasciola hepatica, which is also known as “the common liver fluke” or “the sheep liver fluke” or by Fasciola gigantica.
  • In humans also, it is prescribed to adults and children older than 6 years old who have been diagnosed with fascioliasis, typically found in the liver and bile ducts and is caused by flat worms known as liver flukes.
  • It is also used to treat another food-borne parasitic infection known as paragonimiasis  caused by the lung fluke, most commonly Paragonimus westermani.

Side effects

  • Abdominal pain and headaches are two of the potential side effects, but they are generally uncommon.
  • Biliary colic may occur.
  • Yellowing of the skin or eyes is a potentially serious side effect.

FAQs

Q. Where to buy Triclabendazole?

 Macsen Labs is an ISO-certified supplier of high-quality Triclabendazole.

Q. Is triclabendazole safe in pregnancy?

There is no evidence that using this product during pregnancy is harmful, however, the use of triclabendazole has not been studied extensively in pregnant women.

Q. How does triclabendazole work?

Tricloabendazole’s mechanism of action is similar to that of other benzimidazoles in that it binds to beta-tubulin therefore preventing the polymerization of microtubules and kill the flat worms.

Q. What is the difference between triclabendazole and albendazole?

Albendazole does not immediately appear to have any insecticidal effects on adult Fasciola gigantica, although it may have an impact on the growth of the eggs. Both the adults and the eggs of Fasciola gigantica are susceptible to the anthelmintic effects of triclabendazole. Tricloabendazole also provides the benefits of a strong curative impact, a brief course of treatment, and no overt adverse effects.

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