Valsartan (137862-53-4)

Valsartan Chemical Structure

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What is Valsartan

Valsartan is a nonpeptide triazole-derived antagonist of angiotensin (AT) II receptor with antihypertensive properties. It was patented in 1990 and came into medical use in 1996. It is available as a generic medication. It works by relaxing blood vessels so that blood can flow more easily. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

Valsartan is active orally and is taken by mouth. Valsartan/hydrochlorothiazide, valsartan/amlodipine, valsartan/amlodipine/hydrochlorothiazide, and valsartan/sacubitril are some of the available combinations for medical use.

Macsen Laboratories is the supplier of high-quality Valsartan.
PRODUCT SPECIFICATIONS
Name of Product Valsartan
IUPAC Name (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
Synonyms Diovan; Tareg; Provas; Exforge; Valsartana; valsartán
CAS No 137862-53-4
Molecular Formula C24H29N5O3
Molecular Weight 435.5 g/mol
Pubchem CID 60846

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Color) White
2 Appearance (Form) Solid Powder
3 Melting Point 116-117 °C
4 Solubility Soluble in ethanol, DMSO, and dimethyl formamide
5 Stability/Shelf Life Stable under recommended storage conditions

Uses

  • Valsartan is primarily used to treat high blood pressure and heart failure.
  • It is also used to improve the chance of living longer after a heart attack and reduce mortality rate and heart failure hospitalisations when used alone or in combination with beta-blockers.
  • In people with type 2 diabetes, antihypertensive therapy with valsartan reduce the rate of progression to end-stage kidney disease.

Side effects

Common side effects include:

  • Feeling tired
  • Dizziness or lightheadedness
  • Diarrhoea
  • High blood Potassium (Symptoms include fainting, muscle weakness, slow/irregular heartbeat)
  • Joint Pain

Other potentially harmful side effects include:

Use during pregnancy can be harmful to the infant. Also, Valsartan is not recommended for breastfeeding mothers.

FAQs

Q. Is Valsartan a beta-blocker?

Valsartan is an Angiotensin II receptor blocker (ARBs) used to treat hypertension, heart failure, and heart attack recovery.

Q. Does Valsartan cause weight gain?

Valsartan’s most common adverse effects are minor and short-lived. However, people who used the medicine also suffered weight gain and hair loss.

Q. Why was Valsartan taken off the market?

In July 2018, the FDA announced a voluntary recall of several drugs containing valsartan (Amlodipine/Valsartan Tablets USP, Valsartan HCTZ Tablets, and Valsartan Tablets USP) due to the detection of trace amounts of cancer-causing chemical N-nitrosodiethylamine (NDEA).

The valsartan-containing medications Diovan, Entresto, Exforge, and Exforge HCT are not currently included in the recall.

Q. Is Valsartan safe to take in 2022?

Valsartan is generally considered safe and non-toxic, but the drug should always be taken as per the directions by your physician.

Q. Is Valsartan an ACE inhibitor?

Valsartan is in a class of medications called angiotensin II receptor antagonists. It is not an angiotensin-converting enzyme (ACE) inhibitor.

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