Methylene BluePharmaceutical Grade Leucomethylene Blue Powder (50 gms)

SKU: MAC006

$850.00

LEUCOMAC BLUE – Pharmaceutical grade Leucomethylene Blue (50 gms)

Pharmaceutical Grade Leucomethylene Blue Ascorbate Powder

Ultra-High Purity 

Reduced and Stabilized form of Methylene Blue

Free from Metals, Organic Impurities and Solvents

cGMP Manufactured

Free Shipping Worldwide (Shipping does not include Import Duty)

Description

Ultra High Purity Leucomethylene Blue

  • Reduced and stabilized Vitamin C salt of Methylene Blue- Leucomethylene Blue Ascorbate.
  • Patent free molecule.
  • Pharmaceutical grade and meets ICH requirements for impurities.
  • Reduced form of Methylene Blue having lower toxicity, higher bio-absorption and instant anti-oxidant effect.  
  • It works as a cyclic and regenerative anti-oxidant.
  • Proven mitochondrial anti-ageing activity.

Now available for in-vitro and other research purposes. The product will be packed in food-grade HDPE Jars. This product is shipped in powder form and you can mix it with water for preparing a solution (0.1%, 1%, 2%). Each shipment will be provided with a Batch Certificate of Analysis. 

(This product contains 50 gms of Leucomethylene Blue Ascorbate Powder)

Chemical structure and Properties

Chemical structure of Leucomethylene Blue

SPECIFICATIONS OF LEUCOMETHYLENE BLUE
IUPAC Name 3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine
Synonyms Leucomethylene blue; Panatone; Leukomethylene blue; Hydromethylthionine;Reduced methylene blue; Leuco methylthioninium
CAS No. 613-11-6
Molecular Formula C16H19N3S
Molar Mass 285.4 g/mol
Appearance Colorless to Sky-bluish crystalline powder
Storage Condition Store in refrigerator in a closed container, protected from light
Stability/Shelf Life 6 months to 1 year
UNique Ingredient Identifier (UNII) code IHU4GYZ2R3
PubChem CID 164695

Mechanism: How does it work as a powerful & regenerative antioxidant ?

Leucomethylene blue (LMB) is a phenothiazine derivative and can be oxidized to Methylene blue (MB). It’s one of the very few regenerative anti-oxidant having cyclic redox activity. Because of its hydrophilicity and lipophilicity, it has a high level of permeability through biological membranes. Leucomethylene blue can cycle readily between oxidized and reduced forms in mitochondria by directly transferring its electrons to cytochrome c, and getting re-oxidized to MB. Such characteristics allow it to work as a catalytic redox cycler in mitochondria. As a result, Leuco MB possesses the capacity to protect cells against the harmful effects of oxidative stress brought on by pathogenic circumstances, thus working as a regenerative antioxidant.

Application/ Uses

Methemoglobinemia

Methemoglobinemia is a disorder that occurs when there is a higher-than-normal amount of methemoglobin (a form of haemoglobin that cannot carry oxygen) detected in the blood, which lowers the amount of oxygen that is carried by the blood and has the potential to induce hypoxemia in the tissues.

Methemoglobinemia can be treated with Leucomethylene Blue. It works by oxidizing methemoglobin and converting it back into haemoglobin. For more details, you may refer here.

Alzheimer’s

Leucomethylene blue helps in the treatment of Alzheimer’s by inhibiting ‘Tau’ Protein aggregation and preventing abnormal accumulation of proteins within and around brain cells. For more details, you may refer here.

Malaria

Leucomethylene Blue’s ability to fight malaria has been linked to its antioxidant properties, which selectively target glutathione reductase, a crucial enzyme in the life cycle of Plasmodium falciparum, the parasite that is responsible for the disease. For more details, you may refer here.

Potential for Anti-ageing activity

According to the “free radicals theory of ageing,” the deterioration of cells and tissues with age is caused by the actions of free radicals. During the process of ageing, human cells produce reactive oxygen species (ROS) predominantly in their mitochondria. This results in a decrease in the mass of mitochondria as well as their capacity and efficiency for respiration. Dysfunctional mitochondria lead to decreased ATP production and increased ROS production, which would further damage mitochondria. This vicious loop causes serious harm to the cells of the body and speeds up the ageing process. Due to the fact that it is a powerful antioxidant, MB is able to effectively combat ROS and inhibits the accelerated ageing that is caused by ROS.

Advantages of Leucomethylene blue over Methylene blue

LEUCOMETHYLENE BLUE (LMB)
METHYLENE BLUE (MB)
Leucomethylene Blue itself shows antioxidant properties (Rapid antioxidant effect). MB may take more time as it needs to be reduced to LMB to exhibit its action.
LMB is an instant antioxidant as it rapidly oxidizes to MB, thus should show rapid onset of action. MB may take more time as it needs to be reduced to LMB to exhibit its action.
LMB is effective in methemoglobinemia patients suffering from glucose-6-phosphate dehydrogenase (G6PD) deficiency. MB treatment will not work for those with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Macsen Labs is a manufacturer and supplier of several grades of Methylene Blue compound such as:-

Macsen Labs group’s Methylene Blue Synthesis Process was granted a patent from the Indian patent office

The Indian Patent Office granted a patent to Mr Achal Agrawal, CEO of Macsen Labs, Udaipur. The title of the patent is Novel Improved Method for Synthesis of Diaminophenothiazine Compounds and it concerns a novel process for synthesising the compound Methylthioninium Chloride or Methylene Blue. Macsen Labs has now achieved a unique position by this patent and from now nobody will be able to copy this process. Read more

Resources on Methylene Blue

Methylene Blue | Chemistry, Uses & Side effects

Methylene blue for treating Methemoglobinemia

Methylene Blue & Covid-19 – Research So Far

Staining with Methylene Blue | Different uses and examples

Methylene Blue’s uses in Fish Aquaculture

Methylene Blue Against Cyanide Poisoning

Methylene Blue Injection: Indications, Dosage & Brands

Methylene Blue in the treatment of Alzheimer’s

Malaria Treatment with Methylene Blue

Methylene Blue Treatment for Lumpy Skin disease in cattle

Disclaimer-

We do not claim or recommend any particular use of Leucomethylene Blue. Use in accordance to the prevailing laws of your country/state. The term “pharmaceutical grade” is only to represent the quality of the product and not the use. We sell as API/Bulk drug only to licensed distributors/end users.

This product is not an API, Bulk drug, Pharmaceutical or Medicine.

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