Patent Blue V or Acid Blue 3 is a synthetic triphenylmethane dye. It occurs as dark blue powder or granules. It is principally the calcium or sodium salt of 2-[4-[alpha-(4-diethyl-aminophenyl)-5-hydroxy-2,4-disulfonatophenylmethylidene]-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt, and subsidiary colouring matters. It is also called Food Blue 5, Sulphan Blue, Acid Blue 3, L-Blau 3, C-Blau 20, Patentblau V, or Sky Blue C.I. 42051. It is used as a food additive in certain jelly sweets and gelatin desserts in Europe.
|Name of Product||Patent Blue V|
|Synonyms||Acid Blue 3, C.I. Food Blue 5, Carmine Blue V, Acidal Carmine V, Merantine Blue V|
|Molecular Weight||1159.4 g/mol|
|1||Appearance (Color)||Dark Blue|
|2||Appearance (Form)||Powder or Granules|
|3||UV Spectra||Maximum in water at 638 nm at pH 5|
|4||Total Dye Content (percent by mass)||≥85.0%|
|5||Loss on Drying at 135°C||<45%|
|6||Water Insoluble matter||>0.2%|
|7||Assay||≥97.0% (HPLC)||8||Uses||Food additive, Cosmetic colorant, Dye|
Rash, pruritus, erythema, urticaria, angioedema (such as facial oedema or laryngeal oedema), bronchospasm, tachycardia, reduced blood pressure, and circulatory collapse are the most commonly reported consequences in the setting of a hypersensitive reaction associated with the excessive dosage of Patent Blue V.
Q. What is the use of Patent Blue V in pharmaceuticals?
Patent Blue V is a sterile injectable dye solution. It is a triphenylmethane dye that is used to reveal vessels in order to improve the imaging of certain vessels in your body.
Q. Is Patent Blue the same as Methylene Blue?
Both Patent Blue and Methylene Blue are used as diagnostic agents for the detection of the sentinel lymph node in breast cancer patients. But in contrast to Patent Blue, Methylene Blue is more widely available and much more cost-effective. Also, Patent Blue poses a greater risk of anaphylaxis and hypersensitivity reactions, thus methylene blue is the preferred choice of agent.