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Ascorbyl Glucoside (129499-78-1)

Ascorbyl Glucoside Chemical Structure

What is Ascorbyl Glucoside?

Ascorbyl glucoside (AA-2G) is a derivative of ascorbic acid having at least one glycosyl group in its molecular structure. It is a stable and water-soluble derivative of vitamin C (ascorbic acid) that is commonly used in skincare products.

Macsen Laboratories is the leading supplier of Ascorbyl Glucoside with ISO certification.
Name of Product Ascorbyl Glucoside
IUPAC Name (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2H-furan-5-one
Synonyms Ascorbic acid 2-O-glucoside; 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid; AA-2G; L-Ascorbic acid 2-O-alpha-glucoside
CAS No 129499-78-1
Molecular Formula C12H18O11
Molecular Weight 338.26 g/mol
Pubchem CID 54693473
Pubchem SID 481739573

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Color) White
3 Solubility Soluble in water
4 Density 1.8±0.1 g/cm3
5 Melting Point 158-163°C
6 Loss on Drying NMT 3.0%


Ascorbyl Glucoside is a versatile ingredient that has multiple benefits for the skin and is widely used in various skincare products, including serums, moisturizers, and sunscreens for the following applications-

  • It helps in brightening the skin by inhibiting the production of melanin, reducing hyperpigmentation and dark spots, making the skin appear more even-toned. It also promotes collagen synthesis, which helps in reducing the appearance of fine lines and wrinkles.
  • It is a potent antioxidant that helps in protecting the skin from damage caused by free radicals and environmental stressors.
  • It has anti-inflammatory properties that help in reducing inflammation in the skin and helps in soothing irritated skin.
  • It also has photoprotective properties that help in protecting the skin from the harmful UV rays of the sun.

Side effects

Ascorbyl Glucoside is generally considered safe for topical use in skincare products and is well-tolerated by most individuals. However, some people may experience minimal side effects such as:

  • Mild skin irritation, redness, or itching (especially in people with sensitive skin or in those who are allergic to Vitamin C).
  • Dryness of skin (if used in high concentrations or in combination with other drying ingredients).
  • Increased sensitivity of skin to sunlight (may increase the risk of sunburn and other sun-related skin damage).


Q. Can I mix Ascorbyl glucoside with Niacinamide?

Ascorbyl glucoside and Niacinamide can be used combinedly in a skincare routine. Both together can help to enhance the brightening effects of Vitamin C, while also helping in reducing the appearance of hyperpigmentation and evens skin tone.

Q. What is the difference between Ascorbyl glucoside and Ascorbic acid?

Ascorbyl glucoside and Ascorbic acid are both forms of vitamin C, having some differences in their chemical structures and properties. Ascorbyl glucoside is a stable derivative of ascorbic acid that has been modified by adding a glucose molecule, making it more stable and less prone to oxidation than ascorbic acid. Thus, it has a longer shelf life. Also, it can penetrate the skin more easily than ascorbic acid.

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