Cetylpyridinium chloride (CPC) is a pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It is a cationic quaternary ammonium compound that is commonly used as an antimicrobial agent in various products such as mouthwash, toothpaste, and other oral care products, as well as personal care products, disinfectants, and pharmaceuticals.
It is approved for use by the United States Food and Drug Administration (FDA) and the European Union (EU).
|Name of Product||Cetylpyridinium Chloride|
|Synonyms||1-Hexadecylpyridinium chloride; hexadecylpyridinium chloride; Pristacin; Cetamium; Ceprim; Dobendan; Pyrisept; Tserigel; Aktivex; Biosept; Cepacol|
|Molecular Weight||340.0 g/mol|
|Available variants||Cetylpyridinium Chloride Monohydrate (6004-24-6)|
|1||Appearance (Form)||Solid Powder|
|2||Appearance (Color)||White or Almost White|
|3||Solubility||Very soluble in water and chloroform|
|4||Melting point||77 °C (Anhydrous Form)
80-84 °C (Monohydrate Form)
|5|| Water Content
(By Karl Fischer's Method)
|6||Residue on Ignition||NMT 0.2%|
|7||Heavy Metals||NMT 0.002%|
|8||Assay||99.0% to 102.0%|
Although Cetylpyridinium Chloride (CPC) is generally considered safe when used in recommended doses, it can cause side effects in some individuals. Some of the side effects associated with its use include:
Q. Is Cetylpyridinium chloride safe?
The use of Cetylpyridinium chloride in oral health products is generally considered to be safe. However, it can cause some minimal side effects such as tooth staining and temporary loss of taste.
Q. Does Cetylpyridinium chloride kill good bacteria?
Cetylpyridinium chloride is a broad-spectrum antimicrobial agent that kills bacteria non-selectively. It can kill some beneficial bacteria but is not believed to significantly impact the overall balance of the oral microbiome.
Q. Is Cetylpyridinium chloride safe for dogs?
Q. What is the difference between Cetylpyridinium chloride and Chlorhexidine?
Both Cetylpyridinium chloride (CPC) and Chlorhexidine are effective antimicrobial agents commonly used in oral care products. However, CPC is a milder and less potent antimicrobial agent that is suitable for routine oral care, while Chlorhexidine is more potent and is used in more severe cases of gum disease or infections.
Q. How does Cetylpyridinium chloride kill bacteria?
Cetylpyridinium chloride is a potent antimicrobial agent that works by disrupting the cell membranes and intracellular processes of bacteria and other microorganisms, ultimately leading to their death. It is attracted to the negatively charged membranes of bacteria and can penetrate them, causing the cell contents to leak out and eventually leading to their death.