Chlorphenesin (104-29-0)

Chlorphenesin Chemical Structure

What is Chlorphenesin?

Chemically, Chlorphenesin is a glycerol in which the hydrogen of one of the main hydroxy groups is replaced by a 4-chlorophenyl group. It is used as a preservative in cosmetic products and is permitted by EFSA in Europe and the FDA at a limit of concentration upto 0.3% by weight.

Macsen Laboratories is the leading supplier of Chlorphenesin with ISO certification.
Name of Product Chlorphenesin
IUPAC Name 3-(4-chlorophenoxy)propane-1,2-diol
Synonyms Adermykon; Gecophen; Chlorphenesinum; Clorfenesina; p-Chlorophenyl glyceryl ether; Chlorphénésine
CAS No 104-29-0
Molecular Formula C9H11ClO3
Molecular Weight 202.63 g/mol
Pubchem CID 7697

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Color) White
3 Solubility in Water 10.4 mg/mL
4 Melting Point 86-92°C
5 Log P 1.2


  • Chlorphenesin is a useful ingredient that is commonly used as a preservative in skincare formulations owing to its antifungal and antibacterial properties. It prevents microbial growth and contamination, thus extending the shelf life of products and maintain their safety and efficacy.
  • Chlorphenesin is however thought to be ineffective against some kinds of bacteria and is hence used in combination with with other preservatives, such as phenoxyethanol and caprylyl glycol, to boost stability and increase the product’s shelf life.
  • It is also considered a “cosmetic biocide” for its ability to prevent unpleasant skin odors.
  • It is used in cosmetic products such as aftershave lotions, bath products, deodorants, hair conditioners, makeup, skin care products, eye care cosmetics, personal cleanliness products, and shampoos.

Side effects

  • Some individuals may experience skin irritation or allergic reactions characterized by redness, itching, swelling, or a rash, when using products containing Chlorphenesin.
  • It can be irritating to the eyes, especially if it comes into direct contact. It’s important to avoid getting products containing Chlorphenesin in the eyes and to rinse thoroughly with water if accidental contact occurs.
  • In rare cases, some individuals may experience dryness or a feeling of tightness after using products containing Chlorphenesin.


Q. Is Chlorphenesin safe for skin?

Chlorphenesin is generally considered to be safe for use provided when used in accordance with the recommended concentrations and guidelines. Also, the Cosmetic Ingredient Review Expert Panel concluded in 2014, that it is harmless for skin.

Q. Is Chlorphenesin a paraben?

Chlorphenesin is not a paraben.

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