Piroctone olamine (68890-66-4)

Piroctone olamine Chemical Structure

What is Piroctone olamine?

Piroctone olamine belongs to the class of hydroxypyridone antimycotics. It is the ethanolamine salt of the hydroxamic acid derivative piroctone. It is structurally similar to Ciclopirox and Pyrithione.

Macsen Laboratories is the leading supplier of Piroctone olamine with ISO certification.
Name of Product Piroctone olamine
IUPAC Name 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
Synonyms Octopirox; Piroctone ethanolamine; Octopyrox; Piroctoneolamine
CAS No 68890-66-4
Molecular Formula C16H30N2O3
Molecular Weight 298.42 g/mol
Pubchem CID 50258
Pubchem SID 475523907


SR. No Criteria Limit/Specification
1 Appearance (Form) Crystalline powder
2 Appearance (Color) White or Slightly Yellow
3 Odor Characteristic
4 Solubility Soluble in DMSO and ethanol; Insoluble in water
5 Melting point 134.0 to 138.0 °C
6 pH (1% in water 20°C) 8.5-10.0

Mechanism of action

Dandruff is caused by a fungus called Pityrosporum Ovale. This fungus infection causes a lot of cell growth and rapid scaling, which starts to form on the scalp. When sebum from the skin and dead skin cells mix, dandruff is produced.

Piroctone Olamine is effective against fungi because it is able to break through the cell membrane of the organisms and so disrupt their energy metabolism as well as their ability to take in oxygen. This kills the fungi and clears up the infection.


Piroctone olamine is an agent that has a broad spectrum of activity against bacterial and fungal infections. Thus, it is frequently employed to treat fungal infections and as an antidandruff agent in shampoos. Not only does it efficiently treat dandruff when added to shampoos, but it also gives conditioning benefits for the hair.


Q. Is Piroctone olamine natural?

Piroctone olamine is of petrochemical origin.

Q. Is Piroctone olamine safe?

Piroctone olamine is generally found to be safe and as such no side effects have been reported. However, one should consult their physician before using the products containing piroctone olamine.

Q. What is Climbazole and Piroctone olamine used for?

Climbazole and Piroctone olamine are two antifungal agents used in combination for the treatment and prevention of dandruff.

Q. Is the use of Piroctone olamine safe safe during pregnancy?

Piroctone Olamine is typically safe to use, even for pregnant women; however, before using it, it is recommended that you seek the guidance of a gynecologist.

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