Denatonium benzoate (3734-33-6)

Home »Sourcing Solutions » Denatonium Benzoate

What is Denatonium Benzoate

Denatonium Benzoate is the benzoate salt of quaternary ammonium cation denatonium. It is the most bitter chemical compound known, with a bitterness threshold of 0.05 ppm. The name denatonium reflects the substance’s primary use as a denaturant and its chemical nature as a cation, hence the Latin suffix -onium. It is available under trade names such as Denatrol, BITTERANT-b, BITTER+PLUS, Bitrex, and Aversion. Denatonium salts are usually colourless and odourless solids but are often traded as solutions.

Macsen Laboratories is the supplier of high-quality Denatonium Benzoate.
Name of Product Denatonium Benzoate (Anhydrous)
IUPAC Name benzyl-[2-(2,6-dimethylanilino)-2-oxoethyl]-diethylazanium;benzoate
Synonyms DENATONIUM BENZOAT, Bitrex, Lidocaine benzyl benzoate
CAS No 3734-33-6
Molecular Formula C28H34N2O3
Molecular Weight 446.6 g/mol
Pubchem CID 19518
Pubchem SID 463577164


SR. No Criteria Limit/Specification
1 Appearance White free flowing powder
2 Assay (by Titrimetry (NAT)) Not less than 99.50 % w/w and not more than 101.0 % w/w
3 MELTING POINT 162 °C to 171 °C
4 Loss on Drying NMT 1.0 %
5 pH 6.5 to 7.5


The bitterness of the compound guides most applications of denatonium. Denatonium benzoate (Bitrex) has been used in the United States for over 20 years as an alcohol denaturant. It is also used in clinical trials in placebos to mimic the bitter taste of certain medications. It is also added to many kinds of harmful liquids including solvents such as paints, varnishes, nail polish removers, toiletries, etc to prevent accidental swallowing or choking by children.

Side effects

There are no serious side effects or adverse effects reported with the use of this drug. But People may experience irritability, difficulty sleeping, confusion, nightmares, mood swings, depression, suffer from delusions and suicidal thoughts in case of excessive dosage.


Q. Is Denatonium Benzoate toxic to humans?

When ingested at 10 ppm by human beings, denatonium benzoate has an extremely bitter, unpleasant taste. The addition of denatonium benzoate to liquid dish detergents and orange juice reduces the amount ingested by children. The toxicity of denatonium benzoate is low with acute PO LD50s in rats of 485-740 mg/kg.

Q. Is Denatonium benzoate the same as benzene?

Denatonium benzoate consists of benzoate i.e., the conjugate base of benzoic acid and an ester of two Para-aminobenzoic acid (PABA) molecules.

Q. What products have Denatonium benzoate?

Denatonium Benzoate is a common bittering agent used in a variety of products such as antifreeze, windshield washer fluid, perfume, nail polish, paints, disinfectants, cleaning fluids, rubbing alcohol, paints, varnishes, solvents, and pesticides.

You can enquire about any of our products/services online.

Our team will get back to you within 24 hours.
Website Designed & Developed By: Webtech Softwares Pvt. Ltd. | Digital Marketing Agency
Copyright © 2014-22 Macsen Laboratories.