Dipicolinic acid Chemical Structure

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What is Dipicolinic acid?

Dipicolinic acid (DPA) also referred to as Pyridine-2,6-dicarboxylic acid (PDC), is a pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6. It’s mot common application is to prepare dipicolinato ligated complexes for use in ion chromatography.

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Name of Product Dipicolinic acid
IUPAC Name Pyridine-2,6-dicarboxylic acid
Synonyms 2,6-Pyridinedicarboxylic acid; 2,6-Dipicolinic acid; Dipicolinate; 2,6-Dicarboxypyridine; 2,6-pyridinedicarboxylate
CAS No 499-83-2
Molecular Formula C7H5NO4
Molar Mass 167.12 g/mol
Pubchem CID 10367
Pubchem SID 480474272

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Crystalline powder
2 Appearance (Color) White to off-white
3 Solubility (In water) 5 mg/mL (at 25 °C)
4 Melting Point 248 to 250 °C
5 Sulphated Ash < 1.0%
6 Moisture Content < 0.5%
7 Chromium (Cr) < 10 ppm
8 Iron (Fe) < 50 ppm
9 Assay > 99.0 %


  • Dipicolinic acid plays a biological role in providing heat-resistance property to endospores produced by bacterial pathogens such as the aerobic Bacillus and anaerobic Clostridium. It accomplishes this by forming a complex with calcium ions in the endospore’s core. This complex binds to free water molecules, causing the spore to become dehydrated. Consequently, the thermal resistance of the macromolecules within the nucleus increases.
  • Additionally, it is used to produce complexes of lanthanide and transition metals for ion chromatography.

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