Brilliant Blue G (6104-58-1)

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The suffix “G” in the name is an abbreviation for “green” as the blue colour of the dye has a slight greenish tint. Brilliant Blue G is used to determine the urine protein concentration. After SDS-PAGE (sodium dodecyl sulphate polyacrylamide gel electrophoresis) It has been used to detect protein bands and used as a purinergic receptor antagonist (P2X7R). The receptor is primarily engaged in inflammatory reactions in the brain.

During ophthalmic procedures, BG is used in an ophthalmic solution to stain the internal limiting membrane (ILM) of the eye. The internal limiting membrane (ILM) is a thin, transparent barrier that separates the retina from the eye’s vitreous body.  Since this membrane is thin and transparent, it might be difficult to detect during eye surgeries requiring high degrees of visual precision. The BG gives a strong blue colour, which facilitates the identification of the ILM. On December 20, 2019, the FDA approved it for ophthalmic use. BG stains the eye’s internal limiting membrane (ILM) without colouring the epiretinal membrane or the retina, making surgical removal simpler. The internal limiting membrane (ILM) is a thin, transparent barrier that separates the retina from the eye’s vitreous body.

The product is currently under development. Samples are available from R&D. US DMF will be filed this year.
PRODUCT SPECIFICATIONS
Name of Product Brilliant Blue G
Pharmacopoeial Name Brilliant Blue G
Synonyms Brilliant Blue G , Acid Blue 90, Coomassie Brilliant Blue G,
CAS No 6104-58-1
Molecular Formula C47H48N3NaO7S2
Molecular Weight 854.02 g/mol
Pubchem CID 6324599
Pubchem SID 462770290

SPECIFICATIONS

SR. No Criteria Limit/Specification
1 Appearance (Color) Dark Blue to Very Dark Blue
2 Appearance (Form) Powder
3 Solubility (Form)
1 mg/mL, H2O
Solution
4 Suitability
Suitable for use as a reagent in protein determinations
Suitable
5 Purity (HPLC) ≥ 80 %
6 Storage Temperature Room temp

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