Chemical Structure of Erdosteine

What is Erdosteine ?

Erdosteine is a homocysteine-derived thiol derivative. It is a N-acyl-amino acid with mucolytic and free radical scavenging properties. The two functional sulfhydryl groups in the molecule are released after the first-pass metabolism that turns Erdosteine into its pharmacologically active product Met-I.

The medication is recommended for the treatment of both chronic and acute respiratory diseases in over 40 countries across the globe. It is marketed under many brand names (Esteclin, Erdomed, Erdos, Erdotin, etc.) and is available in different formulations, including 300 mg hard capsules, 300 mg dispersible tablets, 225 mg granulates for oral suspension, and 175 mg/5ml powder for oral suspension.

The product is currently under development.
Name of Product Erdosteine
IUPAC Name 2-[2-oxo-2-[(2-oxothiolan-3-yl)amino]ethyl]sulfanylacetic acid
Synonyms Dithiosteine; Erdosteinum; Mucotec; Vectrine; Edirel; Erdotin; Erdosteína; Erdosteina
CAS No 84611-23-4
Molecular Formula C8H11NO4S2
Molecular Weight 249.3 g/mol
Pubchem CID 65632

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Powder
2 Appearance (Color) White to Beige
3 Solubility Soluble in DMSO (≥ 20.0 mg/mL)
4 Solubility (Turbidity) Clear
5 Storage Temperature 2-8°C


Erdosteine is a pharmaceutical agent that is predominantly employed for its therapeutic effects in mucolysis and inflammation reduction. It is frequently recommended for a range of respiratory ailments, some of the major uses being as follows –

  • Chronic Obstructive Pulmonary Disease (COPD): Erdosteine is often prescribed to manage the symptoms of COPD (a progressive lung disease that includes chronic bronchitis and emphysema) as it helps in reducing the frequency and severity of exacerbations, improves lung function, and eases breathing difficulties.
  • Chronic Bronchitis: Erdosteine is used as a treatment for chronic bronchitis, a condition characterized by persistent inflammation of the airways and excessive mucus production. It helps to make the mucus less viscous, making it easier to cough up and clear from the airways.
  • Respiratory Infections: Erdosteine may be prescribed in the management of respiratory infections, such as acute bronchitis, pneumonia, or sinusitis. By thinning mucus and reducing inflammation, it can help alleviate symptoms and improve recovery.

Side effects

Some of the side effects associated with the use of Erdosteine are –

  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Nausea and Vomiting
  • Headache
  • Increased Sweating
  • Vertigo


Q. What type of drug is Erdosteine?

Erdosteine is a medication that is derived from thiols and is categorized as a mucolytic agent.

Q. Is Erdosteine an antibiotic?

Erdosteine is not an antibiotic. It is an oral mucoactive anti-oxidant molecule, having synergistic action with antibiotic therapy in patients with acute infective exacerbation of chronic bronchitis.

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