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Sodium Tetradecyl Sulfate (1191-50-0)

Sodium Tetradecyl Sulfate Chemical Structure

What is Sodium Tetradecyl Sulfate?

Sodium tetradecyl sulfate (STS) is a widely used anionic surfactant. The compound consists of the sodium salt of the micelle-forming sulfate ester of tetradecanol. It is a class of drug known as a sclerosing agent and is used to treat varicose veins of the lower extremities.

The product is currently under development.
Name of Product Sodium Tetradecyl Sulfate
IUPAC Name sodium;tetradecyl sulfate
Synonyms Sodium myristyl sulfate; Niaproof 4; Tetradecyl sodium sulfate; Texapon K 14; Tetradecyl sulfate sodium salt
CAS No 1191-50-0
Molecular Formula C14H29NaO4S
Molecular Weight 316.43 g/mol
Pubchem CID 23665770


SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Color) White to Off-white
3 Non-ionic Impurities
(By gas chromatography)
NMT 3.0% w/w
4 Sulphated Ash NLT 10.3% to NMT 13.3%
5 Storage Store protected from light


Sodium Tetradecyl Sulfate (STS) is a synthetic detergent that is primarily used as a sclerosing agent, particularly in the treatment of varicose veins and other malformations related to blood vessels. Below are some of the primary uses of Sodium Tetradecyl Sulfate-

  • During the sclerotherapy procedure, it is often used to treat leg varicose and spider veins (at concentrations between 0.1% and 3%). When injected directly into the vein, it damages the endothelium, the inner lining of the blood vessel. This leads to inflammatory destruction of the internal lining of the vein and thrombus formation eventually leading to sclerosis of the vein.
  • In some circumstances, STS may be administered off-label as a sclerotherapy for hemorrhoids.
  • Additionally, some lymphatic malformations, a kind of vascular aberration that impacts the lymphatic system, are treated using STS.
  • In individuals with Ehlers-Danlos syndrome, it is sometimes used to treat the stabilization of joints that frequently dislocate.

Side effects

Side effects associated with the use of Sodium tetradecyl sulfate are –

  • Pain, redness, and swelling at the injection site
  • Bruising around the injection site
  • Mild headache
  • Nausea & vomiting
  • Allergic reactions
  • Pain or swelling in one or both legs
  • Chest pain, sudden cough, wheezing, rapid breathing, fast heart rate


Q. What is 3% sodium tetradecyl sulfate STS?

Sodium tetradecyl sulphate, 3 % STS (SotradecolĀ® , Fibro-VeinĀ®), has been widely used as sclerosing agent since 1946, for the the treatment of small varicose veins of the legs, as well as venous and lymphatic malformations.

Q. What brands are sodium tetradecyl sulphate injections?

Sodium tetradecyl sulfate is marketed under various brand names, including Sotradecol and Trombovar.

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