Indocyanine Green (Iodine free)

Indocyanine Green (Sodium iodide free) Chemical Structure

What is Indocyanine Green (Iodine free) ?

Iodine free Indocyanine Green, also referred to as Monopeak Indocyanine Green (Vert d’indocyanine monopic) is equivalent to Infracyanine®. It is a type of cyanine dye that is specifically utilized in the field of medical diagnostics, particularly in individuals who are allergic to iodine. In contrast to regular Indocyanine Green (ICG) which contains upto 5% of sodium iodide, Monopeak Indocyanine Green is free from sodium iodide.

Macsen Laboratories is the leading manufacturer and supplier of Indocyanine Green (Iodine free) with GMP and ISO certification.
Name of Product Indocyanine green (Iodine free)
Synonyms Infracyanine Green; Monopeak Indocyanine Green; Vert d’indocyanine monopic
CAS No 3599-32-4
Molecular Formula C43H47N2NaO6S2
Molar Mass 774.96 g/mol


SR. No Criteria Limit/Specification
1 Appearance Dark Olive Green or Dark Brown-Red powder
2 Solubility Freely soluble in water
3 Loss On Drying (50°C for 3 hr) NMT 6.0%
4 Related Substance
I. Specified Impurity
a. Acetanilide 0.06 %
b. ICG/KSM-II 0.14 %
c. Impurity (m/z= 348.3) 0.69 %
d. Cyclize Impurity 0.20 %
II. Total Impurity NMT 2.0 %


This Iodine free derivative of Indocyanine Green is used in patients allergic to iodine. It is primarily used in ophthalmology, particularly for enhancing visualization during eye surgery. Its uses include –

  • Retinal Surgery: It aids in the visualization of the internal limiting membrane (ILM) of the retina. This is crucial in surgeries for treating macular holes, epiretinal membranes, and other vitreoretinal disorders. Iodine free Indocyanine green, diluted in 5% glucose, results in an iso-osmolar solution, which is safer for the retina.
  • Choroidal Imaging: In some instances, it can be used in angiography to visualize the choroidal blood vessels.
  • Cataract Surgery: It may assist in highlighting the anterior capsule of the lens during cataract surgery.
The Indocyanine Green (Iodine free) is prepared by our novel process, is GMP produced and complies with the USP standards. Buy the best quality Indocyanine Green (Iodine free) from the world’s leading manufacturer & supplier. For buying, send us an enquiry-

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