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Buparvaquone (88426-33-9)

Buparvaquone Chemical Structure

What is Buparvaquone?

Buparvaquone is a chemical compound belonging to the class of naphthoquinones. It is an antiprotozoal drug related to Atovaquone. It was first manufactured in Great Britain, followed by Germany.

The product is currently under development.
PRODUCT SPECIFICATIONS
Name of Product Buparvaquone
IUPAC Name 3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione
Synonyms Butalex; Buparvaquonum; Buparvacuona; Buparvaquona; BW-720C
CAS No 88426-33-9
Molecular Formula C21H26O3
Molecular Weight 326.4 g/mol
Pubchem CID 71768
Pubchem SID 475729087

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) Light Yellow
3 Melting Point 177-185 °C
4 Solubility Ethanol: Slightly Soluble
DMF: 1 mg/ml
DMSO: 1 mg/ml

Mechanism of Action

Buparvaquone binds to the Qo site of cytochrome b thus inhibiting Coenzyme Q – cytochrome c reductase and blocks the mitochondrial electron transport at complex III ( bc1 complex) of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death.

Uses

  • Buparvaquone is a potential agent for the treatment and prevention of all types of Theileriosis in animals  (Zimbabwean theileriosis, tropical theileriosis) and is being used since the late 1980s.
  • Bovine East Coast fever protozoa can be treated in vitro with Buparvaquone owing to its anti-leishmanial activity.

FAQs

Q. What is the route of administration of Buparvaquone?

Buparvaquone is commonly administered intramuscularly via injection (Brand Name – Butalex Injection).

Q. Is Buparvaquone an antibiotic?

Buparvaquone is an antibiotic. It is an antiprotozoal agent.

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