Buparvaquone is a chemical compound belonging to the class of naphthoquinones. It is an antiprotozoal drug related to Atovaquone. It was first manufactured in Great Britain, followed by Germany.
PRODUCT SPECIFICATIONS | |
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Name of Product | Buparvaquone |
IUPAC Name | 3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione |
Synonyms | Butalex; Buparvaquonum; Buparvacuona; Buparvaquona; BW-720C |
CAS No | 88426-33-9 |
Molecular Formula | C21H26O3 |
Molecular Weight | 326.4 g/mol |
Pubchem CID | 71768 |
Pubchem SID | 475729087 |
SR. No | Criteria | Limit/Specification |
---|---|---|
1 | Appearance (Form) | Solid Powder |
2 | Appearance (Colour) | Light Yellow |
3 | Melting Point | 177-185 °C |
4 | Solubility | Ethanol: Slightly Soluble DMF: 1 mg/ml DMSO: 1 mg/ml |
Buparvaquone binds to the Qo site of cytochrome b thus inhibiting Coenzyme Q – cytochrome c reductase and blocks the mitochondrial electron transport at complex III ( bc1 complex) of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death.
Q. What is the route of administration of Buparvaquone?
Buparvaquone is commonly administered intramuscularly via injection (Brand Name – Butalex Injection).
Q. Is Buparvaquone an antibiotic?
Buparvaquone is an antibiotic. It is an antiprotozoal agent.