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Calcium L-5-Methyltetrahydrofolate (151533-22-1)

Levomefolate Calcium Chemical Structure

What is Calcium L-5-Methyltetrahydrofolate?

Calcium L-5-Methyltetrahydrofolate, also known as L-Methylfolate Calcium or Levomefolate Calcium, is an organic calcium salt of (6S)-5-methyltetrahydrofolic acid. It is sold under the brand name Metafolin and incorporated in Deplin. It is a form of Vitamin B that is used to treat megaloblastic anaemia, depression, as well as renal and hepatic impairment.

The product is currently under development. Samples are available from R&D.
Name of Product Calcium L-5- Methyltetrahydrofolate
IUPAC Name calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
Synonyms Levomefolate Calcium; Calcium levomefolate; Nutrifolin; L-methylfolate Calcium; L-5 MTHF; Bodyfolin; Metafolin; LMCA; Deplin; Extrafolate-S
CAS No 151533-22-1
Molecular Formula C20H23CaN7O6
Molecular Weight 497.5 g/mol
Pubchem CID 135564391
Pubchem SID 473127229

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Powder
2 Appearance (Colour) Off-White to Yellow
3 Solubility Slightly soluble in aqueous acids
4 Melting Point 300 °C (Decomposes)


  • The most prevalent application of levomefolate calcium is for the treatment or prevention of low folate levels, which can be caused by a poor diet, pregnancy, alcoholism, liver illness, certain stomach and intestinal issues, renal dialysis, and other conditions.
  • According to the findings of several studies, the addition of levomefolic acid (L-methylfolate) to a first-line antidepressant results in a moderately enhanced adjunctive antidepressant efficacy.
  • Additionally, it has been considered as a potential treatment for cardiovascular diseases as well as advanced tumors such as breast and colorectal cancers.

Side effects

Using levomefolate calcium can result in some of the common side effects like diarrhoea, headache, nausea, and vomiting. It has also been observed that oral L-methylfolate calcium tablets can cause allergic hypersensitivity in certain people.


Q. What are Levomefolate calcium tablets?

L-methylfolate calcium tablets are a type of medical food that can only be obtained through a doctor’s prescription and are used for the clinical management of metabolic abnormalities linked with mental illnesses including schizophrenia and depression.

Q. What is the combination of drospirenone, ethinyl estradiol, and levomefolate used for?

To prevent pregnancy, a combination of drospirenone, ethinyl estradiol, and levomefolate is utilised. It is a birth control pill that, when taken as directed, prevents conception by containing two hormones: ethinyl estradiol and drospirenone. It functions by preventing a woman’s egg from maturing fully each month.

Q. Is Levomefolate the same as L-Methylfolate?

Levomefolate can also be referred to by its synonym, L-methylfolate.

Q. Is Levomefolate a prescription drug?

Levomefolate Calcium/ Algal Powder Capsules are a prescription folate-containing medication designed for the dietary management of patients with special nutritional needs requiring enhanced folate levels.

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