What is Cromolyn Sodium?
Cromolyn Sodium also referred to as Sodium cromoglycate is the organic sodium salt form of Cromolyn. Roger Altounyan, a pharmacologist suffering from asthma, discovered it in 1965.
It is used as a nasal spray to treat allergic rhinitis, as an inhaler or nebulizer solution to treat and manage asthma, as eye drops for allergic conjunctivitis, and in oral form for allergies.
The product is currently under development. Samples are available from R&D.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Cromolyn Sodium |
| IUPAC Name | disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate |
| Synonyms | CROMOLYN SODIUM, Sodium cromoglycate, Disodium cromoglycate, Intal, Aarane |
| CAS No | 15826-37-6 |
| Molecular Formula | C23H14Na2O11 |
| Molecular Weight | 512.3 g/mol |
| Pubchem CID | 27503 |
| Pubchem SID | 463577010 |
Chemical Properties
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance (Form) | Powder |
| 2 | Appearance (Colour) | Colourless or Slightly Yellow |
| 3 | Solubility | 50 mg/ml in water |
| 4 | Water Content | NMT 10% |
Mechanism of action
It is a mast cell stabilizer having anti-inflammatory activity. This drug inhibits the release of inflammatory chemicals such as histamine, leukotrienes, and other substances that cause hypersensitivity reactions, from mast cells by interfering with the antigen-stimulated calcium transport across the mast cell membrane, thus ultimately preventing allergic reactions.
Uses
- Cromolyn Sodium helps to stop and relieve allergy symptoms like a stuffy or runny nose, as well as sneezing.
- Cromolyn Sodium is used to manage bronchial asthma, allergic rhinitis, and a number of allergic eye disorders, including vernal conjunctivitis, keratitis, and keratoconjunctivitis.
- It is also used for the treatment of Mastocytosis.
- It is used as a treatment for allergic dermatitis, which is a skin condition that can cause eczema.
Side effects
Headache, muscle aches and diarrhoea are the common side effects associated with Cromolyn Sodium. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice symptoms including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
Resources
Cromolyn Sodium | Mechanism of action, Uses & Side effects
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