What is Deferiprone
Deferiprone is a member of the class of 4-pyridones. It is a white to pinkish-white powder which is sparingly soluble in deionized water and has a melting point range of 272°C – 278°C. It is an orally bioavailable bidentate ligand with iron-chelating activity used as a second-line agent in Thalassemia syndromes when iron overload from blood transfusions occurs. Deferiprone binds iron at a molar ratio of 3:1 (ligand: iron) and thus can remove extra iron from the body by adhering to it.
Macsen is the leading manufacturer and supplier of Deferiprone with ISO and GMP certification.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Deferiprone |
| IUPAC Name | 3-hydroxy-1,2-dimethylpyridin-4-one |
| Synonyms | 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone; Ferriprox; 1,2-dimethyl-3-hydroxy-4-pyridone; Deferiprona; défériprone |
| CAS No | 30652-11-0 |
| Molecular Formula | C7H9NO2 |
| Molecular Weight | 139.15 g/mol |
| Pubchem CID | 2972 |
| Pubchem SID | 463821092 |
Chemical Properties
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance | White to pinkish-white powder |
| 2 | Taste | Very bitter taste |
| 3 | Solubility | Maximum water solubility of 16–18 g/L at 24° |
| 4 | Melting Point | 272-278°C |
Uses
This drug is used by persons who have too much iron in their bodies due to recurrent blood transfusions (such as required for those with blood disorders like Thalassemia and Sickle cell anaemia). Blood transfusions aid in the treatment of blood diseases, but they also introduce excess iron into the body. It is critical to eliminate excess iron since high amounts of iron can create health concerns (such as heart failure, liver disease, diabetes, and delayed growth in children). Deferiprone is prescribed if you have difficulty taking other traditional iron-removal medications or if your iron levels remain high even after taking other iron-removal medications.
Side effects
The most common side effects include:
- Red-brown urine (showing that iron is being removed through the urine)
- Nausea (feeling sick)
- Abdominal pain (stomach ache)
- Vomiting
Agranulocytosis (extremely low amounts of granulocytes, a kind of white blood cell) and Neutropenia (low levels of neutrophils, a type of white blood cell that fights infections) are less common but more dangerous adverse effects.
FAQs
Q. What is the dosage of Deferiprone?
The usual Adult Dose for Thalassemia and Iron Overload is:
Initial dose: 25 mg/kg, orally, 3 times a day (total daily dose: 75 mg/kg)
Maximum dose: 33 mg/kg, orally, 3 times a day (total daily dose: 99 mg/kg)
Q. Who manufactures Deferiprone?
Macsen Labs is a GMP and ISO-certified manufacturer and supplier of high-quality Deferiprone.
Q. What is the difference between Deferasirox and Deferiprone?
Deferasirox and Deferiprone are oral iron-chelating agents used to treat chronic iron overload. However, Deferiprone is less expensive compared to Deferasirox and is superior in controlling or reducing myocardial iron load.
Resources
Deferiprone | Mechanism of Action, Uses & Side effects
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