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Isosulfan Blue (68238-36-8)

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Isosulfan Blue Chemical Structure

What is Isosulfan Blue?

Isosulfan Blue is a visual lymphatic imaging agent that is injected into the tumor site’s periphery, where it binds to the lymphatic system and assists in the surgical detection of tumor sentinel nodes by staining them blue.

The product is currently under development. Samples are available from R&D.
Name of Product Isosulfan Blue
IUPAC Name sodium;2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,4-disulfonate
Synonyms Lymphazurin; Sulphan Blue; Sulfanblau; Disulphin Blau; Azul de Isosulfan; Bleu isosulfan; PATENTBLUEVIOLET
CAS No 68238-36-8
Molecular Formula C27H33N2O6S2
Molecular Weight 566.7 g/mol
Pubchem CID 50108
Pubchem SID 462770291


SR. No Criteria Limit/Specification
1 Appearance greenish-blue colour
2 Heat Resistance °C 160°C
3 Density, g/cm3 1.15
4 Residue on 80mesh 5.0 %max
5 Water Soluble 1.0 % max
6 Volatile Matter at 105°C 1.0 %max
7 Tinting Strength 95-105 %


  • It is utilized as a contrast agent to identify lymphatic vessels in teenage varicoceles with high retroperitoneal ligation and to detect lymphatic vessel leakage after surgery.
  • It is used in conjunction with lymphography to see the lymphatic system draining the injection site (in primary and secondary lymphedema of the limbs; chyluria, chylous ascites or chylothorax; lymph node involvement by the main or secondary tumor).

Side effects

Some of the side effects associated with the use of Isosulfan Blue are as follows-

  • Difficulty with swallowing
  • Dizziness
  • Fast heartbeat (Tachycardia)
  • Fast, weak pulse
  • Hives or welts
  • Shortness of breath
  • Tightness in the chest
  • Unusual tiredness or weakness

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