Ketotifen fumarate (34580-14-8)

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Ketotifen Fumarate is the salt of ketotifen (a cycloheptathiophene derivative) with fumaric acid, sold under brand names like Zaditor, Alaway and Zaditen. Ketotifen is a second-generation non-competitive H1-antihistaminic that selectively blocks histamine (H1) receptors and prevents the typical symptoms caused by histamine release. Thus, it exhibits anti-allergy and anti-inflammatory effects. It also serves as a mast cell stabilizer. It was patented in 1970 and came into medical use in 1976.

It is used in the ophthalmic form to treat allergic conjunctivitis. It relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. Orally, it is used to prevent asthma attacks, generally as an add-on medication in the chronic treatment of mild atopic asthma in children.

The product is currently under development. Samples are available from R&D.
Name of Product Ketotifen Fumarate
IUPAC Name (E)-but-2-enedioic acid;2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
Synonyms Zaditen, Ketotifen hydrogen Fumarate, Ketotifen fumarate salt
CAS No 34580-14-8
Molecular Formula C23H23NO5S
Molecular Weight 425.5 g/mol
Pubchem CID 5282408
Pubchem SID 463577159

It is also a functional leukotriene antagonist and a phosphodiesterase inhibitor. Ketotifen may also provide relief for irritable bowel syndrome. The side effects associated with oral use of Ketotifen fumarate include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.

The product is currently under development. Specifications will be available soon.

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