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Lanthanum Carbonate (587-26-8)

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What is Lanthanum Carbonate?

The salt generated by lanthanum(III) cations and carbonate anions is lanthanum carbonate, La2(CO3)3. It occurs as white powder with negligible solubility in water. Lanthanum carbonate decreases the amount of phosphate in your blood caused by kidney disease and is thus used in medicine, available in the form of chewable tablets, to treat hyperphosphatemia. It is sold under the brand name Fosrenol.

Macsen is the manufacturer and supplier of both Lanthanum Carbonate, anhydrous form (CAS No. 587-26-8) and Lanthanum carbonate hydrate form (CAS No. 54451-24-0).

The product is currently under development. Samples are available from R&D. US DMF will be filed this year.
PRODUCT SPECIFICATIONS
Name of Product Lanthanum Carbonate
IUPAC Name lanthanum(3+);tricarbonate
Synonyms Fosrenol; Lanthanum sesquicarbonate; lanthanum(3+) salt (3:2); lanthanum(3+) tricarbonate
CAS No 587-26-8
Molecular Formula La2(CO3)3
Molecular Weight 457.84 gm/mol
Density 2.6–2.7 g/cm3
Pubchem CID 168924
Pubchem SID 462770289

TECHNICAL SPECIFICATIONS

SR. No Criteria Limit/Specification
1 Appearance (Color) White
2 Appearance (Form) powder
3 Nature Hygroscopic
4 Solubility Soluble in acids & Insoluble in water
5 Density 2.6 g/cm3
6 Purity 99%
7 Shelf Life 60 months

Mechanism of action

Lanthanum carbonate is a phosphate binder that acts by decreasing the amount of phosphate that is absorbed by the body. It does this by binding with dietary phosphate and generating insoluble complexes of lanthanum and phosphate which can not be absorbed by the gastrointestinal (GI) tract. Thus, there is a decrease in the serum phosphate levels.

Uses

Side effects

Common side effects associated with the use of Lanthanum Carbonate are-

  • Nausea
  • Vomiting
  • Abdominal Pain

Serious side effects that may occur, include-

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