Methyl Nicotinate (93-60-7)

Methyl Nicotinate Chemical Structure

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What is Methyl Nicotinate

Methyl nicotinate is an aromatic carboxylic acid derivative and a member of pyridines. Chemically, it is a methyl ester of Niacin. It is a natural product found in Chaenomeles speciosaCoffea arabica, and other organisms. It exhibits rubefacient trait through it’s property of causing peripheral vasodilation.

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Name of Product Methyl Nicotinate
IUPAC Name methyl pyridine-3-carboxylate
Synonyms methyl pyridine-3-carboxylate; Nikomet; Nicotinic acid methyl ester; 3-(Methoxycarbonyl)pyridine; Nicometh; nicotinato de metila; nicotinato di metile; nicotinato de metilo; nicotinate de méthyle
CAS No 93-60-7
Molecular Formula C7H7NO2
Molecular Weight 137.14 g/mol
Pubchem CID 7151

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Powder or crystals (possibly with chunks)
2 Appearance (Colour) White to faint yellow
3 Solubility Soluble in water at 20°C 48 g/L.
Soluble in alcohol, chloroform and ethyl acetate.
4 Melting Point 38-43°C
5 Density 0.827g/cm3
6 Log P 0.83
7 Storage Temperature 0-10°C


  • Methyl nicotinate is a rubefacient that is used as an active ingredient in over-the-counter topical treatments for joint and muscle discomfort.
  • It is used in veterinary medicine to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.
  • Additionally, it is used as a flavouring agent in food.
  • It can also be used as a precursor in the synthesis of following compounds:
  1. Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
  2. 5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives.

Side effects

Some of the common side effects associated with use of methyl nicotinate include gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash.

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