What is Methyl Nicotinate
Methyl nicotinate is an aromatic carboxylic acid derivative and a member of pyridines. Chemically, it is a methyl ester of Niacin. It is a natural product found in Chaenomeles speciosa, Coffea arabica, and other organisms. It exhibits rubefacient trait through it’s property of causing peripheral vasodilation.
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| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Methyl Nicotinate |
| IUPAC Name | methyl pyridine-3-carboxylate |
| Synonyms | methyl pyridine-3-carboxylate; Nikomet; Nicotinic acid methyl ester; 3-(Methoxycarbonyl)pyridine; Nicometh; nicotinato de metila; nicotinato di metile; nicotinato de metilo; nicotinate de méthyle |
| CAS No | 93-60-7 |
| Molecular Formula | C7H7NO2 |
| Molecular Weight | 137.14 g/mol |
| Pubchem CID | 7151 |
Chemical Properties
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance (Form) | Powder or crystals (possibly with chunks) |
| 2 | Appearance (Colour) | White to faint yellow |
| 3 | Solubility | Soluble in water at 20°C 48 g/L.
Soluble in alcohol, chloroform and ethyl acetate. |
| 4 | Melting Point | 38-43°C |
| 5 | Density | 0.827g/cm3 |
| 6 | Log P | 0.83 |
| 7 | Storage Temperature | 0-10°C |
Uses
- Methyl nicotinate is a rubefacient that is used as an active ingredient in over-the-counter topical treatments for joint and muscle discomfort.
- It is used in veterinary medicine to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.
- Additionally, it is used as a flavouring agent in food.
- It can also be used as a precursor in the synthesis of following compounds:
- Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
- 5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives.
Side effects
Some of the common side effects associated with use of methyl nicotinate include gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash.
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