Monepantel is a secondary carboxamide produced by the formal condensation of the carboxy group of p-[(trifluoromethyl)sulfanyl]benzoic acid with the amino group of p-[(trifluoromethyl)sulfanyl]benzoic acid (2S) -2-amino-3-hydroxy-2-methylpropanenitrile. It is a nitrile in addition to being an aryl sulphide and an aromatic ether.
|Name of Product||Monepantel|
|Synonyms||ZOLVIX; Monepantelum; Monépantel|
|Molecular Weight||473.4 g/mol|
|1||Appearance (Form)||Solid Powder|
|2||Appearance (Colour)||White to Off-White|
|3||Solubility||Slightly Soluble in Chloroform and Ethyl Acetate|
Monepantel have a novel method of action that involves a unique lineage of nicotinic acetylcholine receptor (nAChR) component ACR-23 that is only found in nematodes. The action of monepantel, which is a positive allosteric modulator of this receptor subunit, causes the receptor to be forced to open in response to a stimulus but is unable to close again. This leads to an uncontrolled flow of ions and, ultimately, a depolarization of the muscle cells, which causes paralysis, spasmodic contractions of the anterior portion of the pharynx, and death in adult nematodes.