What is Monepantel?
Monepantel is a secondary carboxamide produced by the formal condensation of the carboxy group of p-[(trifluoromethyl)sulfanyl]benzoic acid with the amino group of p-[(trifluoromethyl)sulfanyl]benzoic acid (2S) -2-amino-3-hydroxy-2-methylpropanenitrile. It is a nitrile in addition to being an aryl sulphide and an aromatic ether.
The product is currently under development.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Monepantel |
| IUPAC Name | N-[(2S)-2-cyano-1-[5-cyano-2-(trifluoromethyl)phenoxy]propan-2-yl]-4-(trifluoromethylsulfanyl)benzamide |
| Synonyms | ZOLVIX; Monepantelum; Monépantel |
| CAS No | 887148-69-8 |
| Molecular Formula | C20H13F6N3O2S |
| Molecular Weight | 473.4 g/mol |
| Pubchem CID | 44449087 |
| Pubchem SID | 475523905 |
Chemical Properties
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance (Form) | Solid Powder |
| 2 | Appearance (Colour) | White to Off-White |
| 3 | Solubility | Slightly Soluble in Chloroform and Ethyl Acetate |
| 4 | Melting Point | 70-73°C |
Mode of Action
Monepantel have a novel method of action that involves a unique lineage of nicotinic acetylcholine receptor (nAChR) component ACR-23 that is only found in nematodes. The action of monepantel, which is a positive allosteric modulator of this receptor subunit, causes the receptor to be forced to open in response to a stimulus but is unable to close again. This leads to an uncontrolled flow of ions and, ultimately, a depolarization of the muscle cells, which causes paralysis, spasmodic contractions of the anterior portion of the pharynx, and death in adult nematodes.
Uses
- It is a medication that is used to treat helminth infections (anthelmintic).
- It is a nematicide with a broad spectrum of activity and is used to treat and prevent roundworm infections in the gastrointestinal tracts of sheep and goats.
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