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What is Nicorandil?

Nicorandil is a niacinamide derivative. It is a nitrate and ATP-sensitive K+ channel agonist that acts as a vasodilator and antianginal medication. It is available in India, the United Kingdom, Japan, most of Europe, the Philippines, Taiwan, Australia and South Korea. It was patented in 1976 and approved for medical use in 1983. It hasn’t been authorised as a drug by the FDA yet. It’s usually used for those with angina who are still experiencing symptoms despite getting effective anti-anginal therapy and is generally administered through the oral route.

Nicorandil is marketed under the brand names Ikorel (in the United Kingdom, Australia and most of Europe), Angedil (in Romania, Poland), Dancor (in Switzerland), Nikoran, PCA (in India), Aprior (in the Philippines), Nitorubin (in Japan), and Sigmart (in Japan, South Korea, Taiwan and China). Nicorandil is not available in the United States.

The product is currently under development. Samples are available from R&D.
Name of Product Nicorandil
IUPAC Name 2-(pyridine-3-carbonylamino)ethyl nitrate
Pharmacopoeial Name Nicorandil
Synonyms 2-Nicotinamidoethyl nitrate, Nicorandilum, Ikorel, Dancor, Sigmart, Adancor, 2-(nicotinamido)ethyl nitrate, Nicorandilo
CAS No 65141-46-0
Molecular Formula C8H9N3O4
Molecular Weight 211.17 g/mol
Pubchem CID 47528
Pubchem SID 462770288
WHO-GMP Available soon
WC Available soon
DMF Available soon

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Color) White to Beige
2 Appearance (Form) Powder
3 Solubility (Turbidity) Clear
4 Storage Temperature Room Temperature
5 Concentration
≥ 10.0 mg/ml
6 Purity (HPLC) ≥ 97.5 %
7 Identity Confirmed
8 Water Content ≤ 2.0 mol
9 Elemental Composition Pass


Nicorandil is primarily used to treat and prevent Angina pectoris. Angina is chest pain that results from episodes of transient myocardial ischemia which can be caused by diseases such as atherosclerosiscoronary artery disease and aortic stenosis. Vasospasm of the coronary arteries is a common cause of angina. It is also used to reduce the risk of acute coronary syndromes.

Mechanism of Action

Nicorandil’s mechanism of action includes enhancing coronary blood flow by causing prolonged dilatation of both artery resistance and conductive channels.  It has been demonstrated to relax the venous circulatory system, which increases pooling in capacitance vessels with a decrease in preload. Reduced end-diastolic pressure and a lower extravascular component of vascular resistance enhance blood flow and minimise infarct size overall.

Side effects

The side effects associated with Nicorandil are as follows:

  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Weakness
  • Vomiting
  • Palpitations
  • Perianalileal, and peristomal ulceration
  • Severe migraine
  • Toothache
  • Nasal Congestion


Q. Is Nicorandil a beta blocker?

Nicorandil is a potassium channel activator having arterial vasodilator properties. Furthermore, due to the presence of a nitrate group in its chemical composition, nicorandil also exhibits venodilating characteristics.

Q. What does Nicorandil do?

Nicorandil, being a vasodilator drug, works by widening the blood vessels. This increases the supply of blood and oxygen to the heart, thus helping in reducing angina attacks. It can also reduce the risk of further heart conditions.

Q. Is Nicorandil a blood thinner?

Nicorandil is not a blood thinner but is a vasodilatory drug used to treat angina.

Resources on Nicorandil

Nicorandil | Mechanism of action, Uses & Side effects

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