Nitroxoline (4008-48-4)

Nitroxoline Chemical Structure

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What is Nitroxoline

Nitroxoline or 8-Hydroxy-5-nitroquinoline belongs to the class of organic compounds known as nitroquinolines and derivatives. It is a C-nitro compound and a monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. It is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It functions as an antibiotic, an antifungal, and an anti-infective agent.

The product is currently under development. Samples are available from R&D.
PRODUCT SPECIFICATIONS
Name of Product Nitroxoline
IUPAC Name 5-nitroquinolin-8-ol
Synonyms NITROXOLINE, 5-nitroquinolin-8-ol, 8-Hydroxy-5-nitroquinoline, 5-Nitrox, Noxibiol, Nibiol, Noxin, Nitroxlina
CAS No 4008-48-4
Molecular Formula C9H6N2O3
Molecular Weight 190.16 g/mol
Pubchem CID 19910
Pubchem SID 463798107

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) Light Yellow to Dark yellow
3 Solubility Alcohol: very slightly soluble
Diethyl ether: very slightly soluble
Hydrochloric acid: freely soluble (hot)
4 Melting Point 180 °C

Uses

  • It is a urinary antibacterial drug that inhibits the growth of sensitive gram-positive and gram-negative organisms seen in urinary tract infections and also prevents them from spreading.
  • It also exhibits the anti-fungal property by suppressing fungi’s ability to grow or reproduce.
  • It has proven to be very effective at combating biofilm infections.
  • Nitroxoline and its analogues have also been shown to have antiangiogenic properties.
  • With distinct Nitroxoline derivatives exhibiting varying levels of inhibition, Nitroxoline may also prove to be a fresh starting point for future cancer treatment research.

Side effects

Side effects associated with nitroxoline are as follows:

  • Nausea
  • Vomiting
  • Anorexia
  • Abdominal pain
  • Diarrhoea
  • Headache
  • Drowsiness
  • Vertigo
  • Dizziness
  • Nystagmus
  • Rash
  • Urticaria
  • Pruritus
  • Fever, etc.

Consult your healthcare practitioner if you have any adverse effects.

FAQs

Q. Is Nitroxoline an antibiotic?

Nitroxoline is an antibiotic agent.

Q. Is Nitroxoline FDA approved?

Yes, Nitroxoline is an FDA-approved antibiotic that also has anticancer potential.

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