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Nitroxoline Chemical Structure

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What is Nitroxoline

Nitroxoline or 8-Hydroxy-5-nitroquinoline belongs to the class of organic compounds known as nitroquinolines and derivatives. It is a C-nitro compound and a monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. It is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It functions as an antibiotic, an antifungal, and an anti-infective agent.

Macsen Laboratories is world's leading manufacturer and supplier of high quality Nitroxoline.
Name of Product Nitroxoline
IUPAC Name 5-nitroquinolin-8-ol
Synonyms NITROXOLINE, 5-nitroquinolin-8-ol, 8-Hydroxy-5-nitroquinoline, 5-Nitrox, Noxibiol, Nibiol, Noxin, Nitroxlina
CAS No 4008-48-4
Molecular Formula C9H6N2O3
Molecular Weight 190.16 g/mol
Pubchem CID 19910
Pubchem SID 463798107

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Solid Powder
2 Appearance (Colour) Light Yellow to Dark yellow
3 Solubility Alcohol: very slightly soluble
Diethyl ether: very slightly soluble
Hydrochloric acid: freely soluble (hot)
4 Melting Point 180 °C


  • It is a urinary antibacterial drug that inhibits the growth of sensitive gram-positive and gram-negative organisms seen in urinary tract infections and also prevents them from spreading.
  • It also exhibits the anti-fungal property by suppressing fungi’s ability to grow or reproduce.
  • It has proven to be very effective at combating biofilm infections.
  • Nitroxoline and its analogues have also been shown to have antiangiogenic properties.
  • With distinct Nitroxoline derivatives exhibiting varying levels of inhibition, Nitroxoline may also prove to be a fresh starting point for future cancer treatment research.

Side effects

Side effects associated with nitroxoline are as follows:

  • Nausea
  • Vomiting
  • Anorexia
  • Abdominal pain
  • Diarrhoea
  • Headache
  • Drowsiness
  • Vertigo
  • Dizziness
  • Nystagmus
  • Rash
  • Urticaria
  • Pruritus
  • Fever, etc.

Consult your healthcare practitioner if you have any adverse effects.


Q. Is Nitroxoline an antibiotic?

Nitroxoline is an antibiotic agent.

Q. Is Nitroxoline FDA approved?

Yes, Nitroxoline is an FDA-approved antibiotic that also has anticancer potential.

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