What is Penfluridol?
Penfluridol is an antipsychotic medication that belongs to the first generation of the diphenylbutylpiperidine class. It is a diarylmethane derivative was discovered at Janssen Pharmaceutica in 1968.
Its primary application is in the treatment of schizophrenia and other psychotic disorders as part of ongoing maintenance or long-term therapy.
The product is currently under development.
| PRODUCT SPECIFICATIONS | |
|---|---|
| Name of Product | Penfluridol |
| IUPAC Name | 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol |
| Synonyms | Micefal; Penfluridol; Penfluridolum; Semap; Longoperidol |
| CAS No | 26864-56-2 |
| Molecular Formula | C28H27ClF5NO |
| Molecular Weight | 524.0 g/mol |
| Pubchem CID | 33630 |
| Pubchem SID | 473127231 |
Chemical Properties
| SR. No | Criteria | Limit/Specification |
|---|---|---|
| 1 | Appearance (Form) | Powder |
| 2 | Appearance (Colour) | White to Beige |
| 3 | Melting Point | 106.0 to 110.0 °C |
| 4 | Solubility | DMSO: >20 mg/mL H2O: insoluble |
| 5 | Solubility (Turbidity) | Clear |
Mechanism of Action
Penfluridol falls under the category of an antipsychotic drug. It works by inhibiting the function of the chemical messenger dopamine, which is responsible for influencing both thoughts and feelings, within the body. This is facilitated by the drug’s ability to bind with dopamine receptors, so it blocks the mesocortical as well as the mesolimbic dopaminergic pathways.
Uses
Penfluridol is a type of antipsychotic medication. It is employed in the treatment of mental disorders such as schizophrenia and various other types of psychotic disorders.
It is also being used in some research studies as mentioned below:
- To investigate its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells.
- To study its potential to inhibit the growth of metastatic triple-negative breast cancer cells.
- To investigate its impact on the development of glioblastoma cell lines.
Side effects
The side effects associated with the use of Penfluridol are as follows:
- Dizziness, Restlessness
- Sedative action (Sleepiness)
- Gastrointestinal problems including constipation, dry mouth, nausea and vomiting
- Metabolic effects such as weight gain, increased saliva and decrease in blood sugar
- Abnormality of voluntary movements, Convulsions (seizures)
- Muscle stiffness
Blood disorders, severe heart disease, and orthostatic hypotension (sudden lowering of blood pressure on standing) are some of the significant adverse effects that can occur
FAQs
Q. Who should not take Penfluridol?
It is contraindicated in people with preexisting depression or coma of the central nervous system.
Q. What is the dosage of Penfluridol?
Due to its exceptionally long-lasting effects, it is frequently suggested to be taken orally only once each week (q 7 days). The once-weekly dose ranges from 10 to 60 mg.
Q. How should Penfluridol be taken?
It is a tablet to be taken orally, with or without food.
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