Penfluridol (26864-56-2)

Penfluridol Chemical Structure

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What is Penfluridol?

Penfluridol is an antipsychotic medication that belongs to the first generation of the diphenylbutylpiperidine class. It is a diarylmethane derivative was discovered at Janssen Pharmaceutica in 1968.

Its primary application is in the treatment of schizophrenia and other psychotic disorders as part of ongoing maintenance or long-term therapy.

The product is currently under development. Samples are available from R&D.
PRODUCT SPECIFICATIONS
Name of Product Penfluridol
IUPAC Name 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol
Synonyms Micefal; Penfluridol; Penfluridolum; Semap; Longoperidol
CAS No 26864-56-2
Molecular Formula C28H27ClF5NO
Molecular Weight 524.0 g/mol
Pubchem CID 33630
Pubchem SID 473127231

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Powder
2 Appearance (Colour) White to Beige
3 Melting Point 106.0 to 110.0 °C
4 Solubility DMSO: >20 mg/mL
H2O: insoluble
5 Solubility (Turbidity) Clear

Mechanism of Action

Penfluridol falls under the category of an antipsychotic drug. It works by inhibiting the function of the chemical messenger dopamine, which is responsible for influencing both thoughts and feelings, within the body. This is facilitated by the drug’s ability to bind with dopamine receptors, so it blocks the mesocortical as well as the mesolimbic dopaminergic pathways.

Uses

Penfluridol is a type of antipsychotic medication. It is employed in the treatment of mental disorders such as schizophrenia and various other types of psychotic disorders.

It is also being used in some research studies as mentioned below:

  • To investigate its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells.
  • To study its potential to inhibit the growth of metastatic triple-negative breast cancer cells.
  • To investigate its impact on the development of glioblastoma cell lines.

Side effects

The side effects associated with the use of Penfluridol are as follows:

  • Dizziness, Restlessness
  • Sedative action (Sleepiness)
  • Gastrointestinal problems including constipation, dry mouth, nausea and vomiting
  • Metabolic effects such as weight gain, increased saliva and decrease in blood sugar
  • Abnormality of voluntary movements, Convulsions (seizures)
  • Muscle stiffness

Blood disorders, severe heart disease, and orthostatic hypotension (sudden lowering of blood pressure on standing) are some of the significant adverse effects that can occur

FAQs

Q. Who should not take Penfluridol?

It is contraindicated in people with preexisting depression or coma of the central nervous system.

Q. What is the dosage of Penfluridol?

Due to its exceptionally long-lasting effects, it is frequently suggested to be taken orally only once each week (q 7 days). The once-weekly dose ranges from 10 to 60 mg.

Q. How should Penfluridol be taken?

It is a tablet to be taken orally, with or without food.

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