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Viloxazine hydrochloride (35604-67-2)

Viloxazine hydrochloride Chemical Structure

What is Viloxazine hydrochloride?

Viloxazine hydrochloride, sold under the brand name Qelbree and formerly as Vivalan among others, is a morpholine derivative. It is a noradrenergic drug prescribed to treat attention deficit hyperactivity disorder (ADHD) in children and adults. Viloxazine is a non-stimulant medication; it has no known misuse liability and is not a controlled substance.

In Europe, it was sold as an antidepressant from 1974 until 2002, when it was discontinued for commercial reasons. It was repurposed for the treatment of ADHD and reintroduced in April 2021 in the United States.

The product is currently under development. Samples are available from R&D.
Name of Product Viloxazine hydrochloride
IUPAC Name 2-[(2-ethoxyphenoxy)methyl]morpholine;hydrochloride
Synonyms Viloxazine HCl; Emovit; Vicilan; Vivalan; Viloxacina clorhidrato; Cloridrato de Viloxazina; Chlorhydrate de viloxazine
CAS No 35604-67-2
Molecular Formula C13H20ClNO3
Molecular Weight 273.75 g/mol
Pubchem CID 71424
Pubchem SID 473127228

Chemical Properties

SR. No Criteria Limit/Specification
1 Appearance (Form) Powder
2 Appearance (Colour) White to beige
3 Solubility DMSO: 2 mg/mL, clear
4 Melting Point 186-188 °C
5 Long storage temp. 2-8°C, dark


Side effects

Side effects observed in children (aged 6-17 years) are as follows:

  • Headache
  • Somnolence
  • Fatigue
  • Nausea, Vomiting
  • Upper respiratory tract infections
  • Decreased appetite

Side effects observed in adults are as follows:


Q. Is Viloxazine FDA approved ?

In april 2021, Qelbree (viloxazine) has been licenced by the FDA to treat children and adults with attention-deficit hyperactivity disorder (ADHD).

Q. Is Viloxazine a controlled substance ?

Viloxazine is not a controlled substance.

Q. Is Qelbree an antidepressant?

Qelbree is a member of the class of antidepressants known as serotonin-norepinephrine reuptake inhibitors. However, it is not authorized for use as a treatment for depression by the Food and Drug Administration (FDA).

Q. Where to purchase Viloxazine hydrochloride ?

Macsen Labs is a GMP and ISO certified manufacturer and supplier of high-quality Viloxazine hydrochloride.


Viloxazine | Mechanism of action, ADHD & other Uses, Side effects

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